Genotyping, Orientalis-like Yersinia pestis, and Plague Pandemics
Michel Drancourt
(1)
,
Véronique Roux
(1)
,
Vu Dang La
(1)
,
Lam Tran-Hung
(1)
,
Dominique Castex
(2)
,
Viviane Chenal-Francisque
(3)
,
Hiroyuki Ogata
(4)
,
Pierre-Edouard Fournier
(1)
,
Eric Crubézy
(5)
,
Didier Raoult
(1)
Michel Drancourt
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- PersonId : 182550
- IdHAL : michel-drancourt
- ORCID : 0000-0003-0768-1139
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Dominique Castex
- Fonction : Auteur
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Viviane Chenal-Francisque
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- IdHAL : vchenalfrancisque
- ORCID : 0000-0002-8190-8875
Hiroyuki Ogata
- Fonction : Auteur
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- ORCID : 0000-0001-6594-377X
Pierre-Edouard Fournier
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Eric Crubézy
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Didier Raoult
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Résumé
Three pandemics have been attributed to plague in the last 1,500 years. Yersinia pestis caused the third, and its DNA was found in human remains from the second. The Antiqua biovar of Y. pestis may have caused the first pandemic; the other two biovars, Medievalis and Orientalis, may have caused the second and third pandemics, respectively. To test this hypothesis, we designed an original genotyping system based on intergenic spacer sequencing called multiple spacer typing (MST). We found that MST differentiated every biovar in a collection of 36 Y. pestis isolates representative of the three biovars. When MST was applied to dental pulp collected from remains of eight persons who likely died in the first and second pandemics, this system identified original sequences that matched those of Y. pestis Orientalis. These data indicate that Y. pestis caused cases of Justinian plague. The two historical plague pandemics were likely caused by Orientalis-like strains.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Genotyping, Orientalis-like Yersinia pestis, and Plague Pandemics
|
Résumé |
en
Three pandemics have been attributed to plague in the last 1,500 years. Yersinia pestis caused the third, and its DNA was found in human remains from the second. The Antiqua biovar of Y. pestis may have caused the first pandemic; the other two biovars, Medievalis and Orientalis, may have caused the second and third pandemics, respectively. To test this hypothesis, we designed an original genotyping system based on intergenic spacer sequencing called multiple spacer typing (MST). We found that MST differentiated every biovar in a collection of 36 Y. pestis isolates representative of the three biovars. When MST was applied to dental pulp collected from remains of eight persons who likely died in the first and second pandemics, this system identified original sequences that matched those of Y. pestis Orientalis. These data indicate that Y. pestis caused cases of Justinian plague. The two historical plague pandemics were likely caused by Orientalis-like strains.
|
Auteur(s) |
Michel Drancourt
1
, Véronique Roux
1
, Vu Dang La
1
, Lam Tran-Hung
1
, Dominique Castex
2
, Viviane Chenal-Francisque
3
, Hiroyuki Ogata
4
, Pierre-Edouard Fournier
1
, Eric Crubézy
5
, Didier Raoult
1
1
Université de la Méditerranée - Aix-Marseille 2
( 5033 )
- 58, boulevard Charles Livon - 13284 Marseille cedex 07
- France
2
PACEA -
De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie
( 205557 )
- Université de Bordeaux - Bâtiment B8 - CS50023 - Allée Geoffroy-Saint-Hilaire - 33615 Pessac Cedex
- France
3
Yersinia
( 10869 )
- Département Microbiologie - 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15
- France
4
IGS -
Information génomique et structurale
( 447 )
- Parc Scientifique de Luminy
163 Avenue de Luminy
Case 934
13288 Marseille Cedex 09
- France
5
LA -
Laboratoire d'Anthropobiologie
( 31348 )
- 37 allées Jules Guesde 31400 Toulouse
- France
|
Page/Identifiant |
1585-1592
|
Volume |
10
|
Numéro |
9
|
Langue du document |
Anglais
|
Date de production/écriture |
2004
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2004
|
Domaine(s) |
|
Mots-clés |
en
Genotyping, Yersinia pestis, Plague Pandemics
|
DOI | 10.3201/eid1009.030933 |
Pubmed Id | 15498160 |
PubMed Central | PMC3320270 |
Origine :
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