Age-Related Changes in Locomotor Performance Reveal a Similar Pattern for Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens
Adrien Marck
(1, 2, 3)
,
Geoffroy C.B. Berthelot
(1, 2)
,
Vincent Foulonneau
(1, 2)
,
Andy Marc
(1, 2)
,
Juliana Antero
(1, 2)
,
Philippe Noirez
(1, 2)
,
Anne M. Bronikowski
(4)
,
Theodore J. Morgan
(5)
,
Theodore Garland Jr.
(6)
,
Patrick A. Carter
(7)
,
Pascal Hersen
(3)
,
Jean-Marc Di Meglio
(3)
,
Jean-François Toussaint
(1, 2)
1
INSEP -
Institut national du sport, de l'expertise et de la performance
2 IRMES - EA 7329 - Institut de recherche biomédicale et d’épidémiologie du sport
3 MSC - Matière et Systèmes Complexes
4 ISU - Iowa State University
5 Kansas State University
6 UC Riverside - University of California [Riverside]
7 WSU - Washington State University
2 IRMES - EA 7329 - Institut de recherche biomédicale et d’épidémiologie du sport
3 MSC - Matière et Systèmes Complexes
4 ISU - Iowa State University
5 Kansas State University
6 UC Riverside - University of California [Riverside]
7 WSU - Washington State University
Geoffroy C.B. Berthelot
- Fonction : Auteur
- PersonId : 182881
- IdHAL : geoffroy-berthelot
- ORCID : 0000-0003-4036-6114
- IdRef : 174431864
Vincent Foulonneau
- Fonction : Auteur
- PersonId : 1032084
Andy Marc
- Fonction : Auteur
- PersonId : 19038
- IdHAL : andy-marc
- ORCID : 0000-0002-9714-6107
Juliana Antero
- Fonction : Auteur
- PersonId : 741713
- IdHAL : juliana-antero
- ORCID : 0000-0001-6894-6693
Philippe Noirez
- Fonction : Auteur
- PersonId : 739676
- IdHAL : philippe-noirez
- ORCID : 0000-0003-4538-803X
- IdRef : 185341659
Pascal Hersen
- Fonction : Auteur
- PersonId : 178483
- IdHAL : hersen-pascal
- ORCID : 0000-0003-2379-4280
- IdRef : 08928707X
Jean-Marc Di Meglio
- Fonction : Auteur
- PersonId : 829670
- ORCID : 0000-0003-0446-4550
- IdRef : 035679514
Jean-François Toussaint
- Fonction : Auteur
- PersonId : 1041396
Résumé
Locomotion is one of the major physiological functions for most animals. Previous studies have described aging mechanisms linked to locomotor performance among different species. However, the precise dynamics of these age-related changes, and their interactions with development and senescence, are largely unknown. Here, we use the same conceptual framework to describe locomotor performances in Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens. We show that locomotion is a consistent biomarker of age-related changes, with an asymmetrical pattern throughout life, regardless of the type of effort or its duration. However, there is variation (i) among species for the same mode of locomotion, (ii) within species for different modes of locomotion, and (iii) among individuals of the same species for the same mode of locomotion. Age-related patterns are modulated by genetic (such as selective breeding) as well as environmental conditions (such as temperature). However, in all cases, the intersection of the rising developmental phase and the declining senescent phase reveals neither a sharp transition nor a plateau, but a smooth transition, emphasizing a crucial moment: the age at peak performance. This transition may define a specific target for future investigations on the dynamics of such biological interactions.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
Locomotion is one of the major physiological functions for most animals. Previous studies have described aging mechanisms linked to locomotor performance among different species. However, the precise dynamics of these age-related changes, and their interactions with development and senescence, are largely unknown. Here, we use the same conceptual framework to describe locomotor performances in Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens. We show that locomotion is a consistent biomarker of age-related changes, with an asymmetrical pattern throughout life, regardless of the type of effort or its duration. However, there is variation (i) among species for the same mode of locomotion, (ii) within species for different modes of locomotion, and (iii) among individuals of the same species for the same mode of locomotion. Age-related patterns are modulated by genetic (such as selective breeding) as well as environmental conditions (such as temperature). However, in all cases, the intersection of the rising developmental phase and the declining senescent phase reveals neither a sharp transition nor a plateau, but a smooth transition, emphasizing a crucial moment: the age at peak performance. This transition may define a specific target for future investigations on the dynamics of such biological interactions.
|
Titre |
en
Age-Related Changes in Locomotor Performance Reveal a Similar Pattern for Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens
|
Auteur(s) |
Adrien Marck
1, 2, 3
, Geoffroy C.B. Berthelot
1, 2
, Vincent Foulonneau
1, 2
, Andy Marc
1, 2
, Juliana Antero
1, 2
, Philippe Noirez
1, 2
, Anne M. Bronikowski
4
, Theodore J. Morgan
5
, Theodore Garland Jr.
6
, Patrick A. Carter
7
, Pascal Hersen
3
, Jean-Marc Di Meglio
3
, Jean-François Toussaint
1, 2
1
INSEP -
Institut national du sport, de l'expertise et de la performance
( 441096 )
- 11 Avenue du Tremblay
75012 Paris
- France
2
IRMES - EA 7329 -
Institut de recherche biomédicale et d’épidémiologie du sport
( 415984 )
- Institut National du Sport, de l’Expertise et de la Performance (INSEP)
11 avenue du Tremblay
75012 Paris
- France
3
MSC -
Matière et Systèmes Complexes
( 170 )
- Université Paris Diderot, Bât. Condorcet, case postale 7056, 10 rue Alice Domon et Léonie Duquet, 75205 PARIS Cedex 13
- France
4
ISU -
Iowa State University
( 302747 )
- Ames, Iowa 50011
- États-Unis
5
Kansas State University
( 365659 )
- États-Unis
6
UC Riverside -
University of California [Riverside]
( 300446 )
- 900 University Ave. Riverside, CA 92521
- États-Unis
7
WSU -
Washington State University
( 303893 )
- Pullman, WA
- États-Unis
|
Audience |
Internationale
|
Comité de lecture |
Oui
|
Vulgarisation |
Non
|
Langue du document |
Anglais
|
Date de publication |
2016
|
Volume |
72
|
Nom de la revue |
|
Numéro |
4
|
Page/Identifiant |
455-463
|
Domaine(s) |
|
Mots-clés |
en
Exercise physiology, Senescence, Epidemiology, Comparative biology, Aging
|
DOI | 10.1093/gerona/glw136 |
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)
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