The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans Authors' names and affiliations
Jean-Francois Moreau
(1, 2)
,
Thomas Pradeu
(3, 1)
,
Andrea Grignolio
(4)
,
Christine Nardini
(5)
,
Filippo Castiglione
(6)
,
Paolo Tieri
(6)
,
Miriam Capri
(7)
,
Stefano Salvioli
(8, 9)
,
Jean-Luc Taupin
(10)
,
Paolo Garagnani
(11)
,
Claudio Franceschi
(11)
1
ImmunoConcept -
Immunology from Concept and Experiments to Translation
2 CHU Bordeaux
3 IHPST - Institut d'Histoire et de Philosophie des Sciences et des Techniques
4 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
5 Phys-ENS - Laboratoire de Physique de l'ENS Lyon
6 POLIMI - Politecnico di Milano [Milan]
7 CIG - Interdepartmental Center “L.Galvani”
8 CIG - Centro Interdipartimentale Galvani
9 Departmento of Experimental, Diagnostic and Specialty Medicine
10 A2T - Alloimmunité-Autoimmunité-Transplantation
11 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
2 CHU Bordeaux
3 IHPST - Institut d'Histoire et de Philosophie des Sciences et des Techniques
4 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
5 Phys-ENS - Laboratoire de Physique de l'ENS Lyon
6 POLIMI - Politecnico di Milano [Milan]
7 CIG - Interdepartmental Center “L.Galvani”
8 CIG - Centro Interdipartimentale Galvani
9 Departmento of Experimental, Diagnostic and Specialty Medicine
10 A2T - Alloimmunité-Autoimmunité-Transplantation
11 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
Jean-Francois Moreau
- Fonction : Auteur
- PersonId : 994543
Thomas Pradeu
- Fonction : Auteur
- PersonId : 9251
- IdHAL : thomaspradeu
- ORCID : 0000-0002-6590-3281
- IdRef : 099535114
Claudio Franceschi
- Fonction : Auteur
- PersonId : 762867
- ORCID : 0000-0001-9841-6386
- IdRef : 172478790
Résumé
Immunosenescence is thought to result from cellular aging and to reflect exposure to environmental stressors and antigens, including cytomegalovirus (CMV). However, not all of the features of immunosenescence are consistent with this view, and this has led to the emergence of the sister theory of " inflammaging ". The recently discovered diffuse tissue distribution of resident memory T cells (TRM) which don't recirculate, calls these theories into question. These cells account for most T cells residing in barrier epithelia which sit in and travel through the extracellular matrix (ECM). With almost all studies to date carried out on peripheral blood, the age-related changes of the ECM and their consequences for T cell mobility, which is crucial for the function of these cells, have been largely ignored. We propose an update of the theoretical framework of immunosenescence, based on a novel hypothesis: the increasing stiffness and cross-linking of the senescent ECM lead to a progressive immunodeficiency due to an age-related decrease in T cell mobility and eventually the death of these cells. A key element of this mechanism is the mechanical stress to which the cell cytoplasm and nucleus are subjected during passage through the ECM. This hypothesis is based on an " evo-devo " perspective bringing together some major characteristics of aging, to create a single interpretive framework for immunosenescence.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans Authors' names and affiliations
|
Résumé |
en
Immunosenescence is thought to result from cellular aging and to reflect exposure to environmental stressors and antigens, including cytomegalovirus (CMV). However, not all of the features of immunosenescence are consistent with this view, and this has led to the emergence of the sister theory of " inflammaging ". The recently discovered diffuse tissue distribution of resident memory T cells (TRM) which don't recirculate, calls these theories into question. These cells account for most T cells residing in barrier epithelia which sit in and travel through the extracellular matrix (ECM). With almost all studies to date carried out on peripheral blood, the age-related changes of the ECM and their consequences for T cell mobility, which is crucial for the function of these cells, have been largely ignored. We propose an update of the theoretical framework of immunosenescence, based on a novel hypothesis: the increasing stiffness and cross-linking of the senescent ECM lead to a progressive immunodeficiency due to an age-related decrease in T cell mobility and eventually the death of these cells. A key element of this mechanism is the mechanical stress to which the cell cytoplasm and nucleus are subjected during passage through the ECM. This hypothesis is based on an " evo-devo " perspective bringing together some major characteristics of aging, to create a single interpretive framework for immunosenescence.
|
Auteur(s) |
Jean-Francois Moreau
1, 2
, Thomas Pradeu
3, 1
, Andrea Grignolio
4
, Christine Nardini
5
, Filippo Castiglione
6
, Paolo Tieri
6
, Miriam Capri
7
, Stefano Salvioli
8, 9
, Jean-Luc Taupin
10
, Paolo Garagnani
11
, Claudio Franceschi
11
1
ImmunoConcept -
Immunology from Concept and Experiments to Translation
( 473693 )
- 146, rue Léo Saignat - 33076 Bordeaux Cedex - France
- France
2
CHU Bordeaux
( 300122 )
- 12 rue Dubernat
33400 Talence
- France
3
IHPST -
Institut d'Histoire et de Philosophie des Sciences et des Techniques
( 1342 )
- 13 Rue du four
75006 PARIS
- France
4
UNIROMA -
Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
( 229915 )
- Piazzale Aldo Moro 5, 00185 Roma
- Italie
5
Phys-ENS -
Laboratoire de Physique de l'ENS Lyon
( 13 )
- 46 allée d'Italie 69007 Lyon
- France
6
POLIMI -
Politecnico di Milano [Milan]
( 125443 )
- Piazza Leonardo da Vinci, 32 20133 Milano
- Italie
7
CIG - Interdepartmental Center “L.Galvani”
( 119906 )
- Italie
8
CIG -
Centro Interdipartimentale Galvani
( 39732 )
- Italie
9
Departmento of Experimental, Diagnostic and Specialty Medicine
( 261776 )
- Italie
10
A2T -
Alloimmunité-Autoimmunité-Transplantation
( 245898 )
- Institut Universitaire d’Hématologie (IUH) - Université Paris Diderot - 1 avenue Claude Vellefaux 75010 Paris
- France
11
UNIBO -
Alma Mater Studiorum Università di Bologna = University of Bologna
( 30978 )
- Via Zamboni, 33 - 40126 Bologna
- Italie
|
URL éditeur |
http://www.sciencedirect.com/science/article/pii/S1568163716301015
|
Page/Identifiant |
322-335
|
Volume |
35
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2017
|
Date de publication électronique |
2016-11-19
|
Vulgarisation |
Non
|
Nom de la revue |
|
Langue du document |
Anglais
|
Projet(s) Européen(s) |
|
Domaine(s) |
|
Mots-clés |
en
Mobility, Immune cells, Aging, Immunosenescence, Extracellular matrix
|
DOI | 10.1016/j.arr.2016.11.005 |
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Moreau et al_The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans.pdf ( 1.03 Mo
)
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