Human tuberculosis predates domestication in ancient Syria
Oussama Baker
(1)
,
Oona Y.-C Lee
(2)
,
Houdini H.T. Wu
(2)
,
Gurdyal S. Besra
(2)
,
David E. Minnikin
(2)
,
Gareth Llewellyn
(3)
,
Christopher M. Williams
(3)
,
Frank Maixner
(4)
,
Niall O'Sullivan
(4)
,
Albert Zink.
(4)
,
Bérénice Chamel
(5)
,
Rima Khawam
(5)
,
Eric Coqueugniot
(5)
,
Daniel Helmer
(5)
,
Françoise Le Mort
(5)
,
Pascale Perrin
(6)
,
Lionel Gourichon
(7)
,
Bruno Dutailly
(8)
,
György Palfi
(9)
,
Hélène Coqueugniot
(8, 10)
,
Olivier Dutour
(1, 8, 11)
1
EPHE -
École Pratique des Hautes Études
2 University of Birmingham [Birmingham]
3 Swansea University
4 Institute for Mummies and the Iceman
5 Archéorient - ARCHEORIENT - Environnements et sociétés de l'Orient ancien
6 MIVEGEC-EVCO - Evolution of host-microbe communities
7 CEPAM - Culture et Environnements, Préhistoire, Antiquité, Moyen-Age
8 PACEA - De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie
9 University of Szeged [Szeged]
10 Department of Human Evolution [Leipzig]
11 UWO - University of Western Ontario
2 University of Birmingham [Birmingham]
3 Swansea University
4 Institute for Mummies and the Iceman
5 Archéorient - ARCHEORIENT - Environnements et sociétés de l'Orient ancien
6 MIVEGEC-EVCO - Evolution of host-microbe communities
7 CEPAM - Culture et Environnements, Préhistoire, Antiquité, Moyen-Age
8 PACEA - De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie
9 University of Szeged [Szeged]
10 Department of Human Evolution [Leipzig]
11 UWO - University of Western Ontario
Bérénice Chamel
- Fonction : Auteur
- PersonId : 942039
- IdHAL : berenice-chamel
- ORCID : 0009-0008-4864-7766
Eric Coqueugniot
- Fonction : Auteur
- PersonId : 857149
Françoise Le Mort
- Fonction : Auteur
- PersonId : 20668
- IdHAL : francoise-le-mort
- IdRef : 142494623
Pascale Perrin
- Fonction : Auteur
- PersonId : 738683
- IdHAL : pascale-perrin
- ORCID : 0000-0002-8328-6504
Lionel Gourichon
- Fonction : Auteur
- PersonId : 178632
- IdHAL : lionel-gourichon
- ORCID : 0000-0002-5160-5902
- IdRef : 103295658
Bruno Dutailly
- Fonction : Auteur
- PersonId : 183215
- IdHAL : dutailly-bruno
- ORCID : 0000-0003-4622-140X
- IdRef : 198270178
Hélène Coqueugniot
- Fonction : Auteur
- PersonId : 738519
- IdHAL : helene-coqueugniot
- ORCID : 0000-0002-1844-4588
- IdRef : 052619230
Olivier Dutour
- Fonction : Auteur
- PersonId : 792178
- ORCID : 0000-0001-8134-788X
- IdRef : 029722756
Résumé
The question of pre-neolithic tuberculosis is still open in paleopathological perspective. One of the major interests is to explore what type of infection could have existed around the early stage of animal domestication. Paleopathological lesions evoking skeletal TB were observed on five human skeletons coming from two PPNB sites in Syria, which belongs to the geographical cradle of agriculture. These sites represent respectively pre-domestication phase (Dja'de el Mughara, Northern Syria, 8800-8300 BCE cal.) and early domestication phase (Tell Aswad, Southern Syria, 8200-7600 BCE cal.). MicroCT scan analyses were performed on two specimens (one per site) and revealed microscopic changes in favor of TB infection. Detection of lipid biomarkers is positive for two specimens (one per site). Initial molecular analysis further indicates the presence of TB in one individual from Dja'de. Interestingly, no morphological evidence of TB was observed on animal remains of wild and newly domesticated species, discovered in these sites. These observations strongly suggest the presence of human tuberculosis before domestication and at its early stages.
Domaines
Anthropologie biologique Archéologie et Préhistoire Maladies infectieuses Microbiologie et Parasitologie GénétiqueFormat du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Human tuberculosis predates domestication in ancient Syria
|
Résumé |
en
The question of pre-neolithic tuberculosis is still open in paleopathological perspective. One of the major interests is to explore what type of infection could have existed around the early stage of animal domestication. Paleopathological lesions evoking skeletal TB were observed on five human skeletons coming from two PPNB sites in Syria, which belongs to the geographical cradle of agriculture. These sites represent respectively pre-domestication phase (Dja'de el Mughara, Northern Syria, 8800-8300 BCE cal.) and early domestication phase (Tell Aswad, Southern Syria, 8200-7600 BCE cal.). MicroCT scan analyses were performed on two specimens (one per site) and revealed microscopic changes in favor of TB infection. Detection of lipid biomarkers is positive for two specimens (one per site). Initial molecular analysis further indicates the presence of TB in one individual from Dja'de. Interestingly, no morphological evidence of TB was observed on animal remains of wild and newly domesticated species, discovered in these sites. These observations strongly suggest the presence of human tuberculosis before domestication and at its early stages.
|
Auteur(s) |
Oussama Baker
1
, Oona Y.-C Lee
2
, Houdini H.T. Wu
2
, Gurdyal S. Besra
2
, David E. Minnikin
2
, Gareth Llewellyn
3
, Christopher M. Williams
3
, Frank Maixner
4
, Niall O'Sullivan
4
, Albert Zink.
4
, Bérénice Chamel
5
, Rima Khawam
5
, Eric Coqueugniot
5
, Daniel Helmer
5
, Françoise Le Mort
5
, Pascale Perrin
6
, Lionel Gourichon
7
, Bruno Dutailly
8
, György Palfi
9
, Hélène Coqueugniot
8, 10
, Olivier Dutour
1, 8, 11
1
EPHE -
École Pratique des Hautes Études
( 110691 )
- 4-14 Rue Ferrus, 75014 Paris
- France
2
University of Birmingham [Birmingham]
( 421435 )
- Edgbaston
Birmingham B15 2TT
- Royaume-Uni
3
Swansea University
( 322817 )
- Singleton Park
Swansea
SA2 8PP Wales
- Royaume-Uni
4
Institute for Mummies and the Iceman
( 478711 )
- Italie
5
Archéorient -
ARCHEORIENT - Environnements et sociétés de l'Orient ancien
( 619 )
- Maison de l'Orient et de la Méditerranée Jean-Pouilloux 7 rue Raulin 69365 LYON Cedex 07
- France
6
MIVEGEC-EVCO -
Evolution of host-microbe communities
( 1052800 )
- France
7
CEPAM -
Culture et Environnements, Préhistoire, Antiquité, Moyen-Age
( 199355 )
- Université Côte d'Azur Pôle universitaire Saint-Jean-d'Angély - SJA3 24, avenue des Diables Bleus 06357 Nice Cedex 4
- France
8
PACEA -
De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie
( 205557 )
- Université de Bordeaux - Bâtiment B8 - CS50023 - Allée Geoffroy-Saint-Hilaire - 33615 Pessac Cedex
- France
9
University of Szeged [Szeged]
( 63200 )
- Dugonics square 13 H-6720 Szeged
- Hongrie
10
Department of Human Evolution [Leipzig]
( 86037 )
- Deutscher Platz 6, D-04103 Leipzig, Germany
- Allemagne
11
UWO -
University of Western Ontario
( 318728 )
- 1151 Richmond St, London, ON, N6A 3K7, Canada
- Canada
|
Langue du document |
Anglais
|
Nom de la revue |
|
Volume |
95
|
Page/Identifiant |
S4-S12
|
Date de publication |
2015
|
Date de publication électronique |
2015
|
URL éditeur |
http://dx.doi.org/10.1016/j.tube.2015.02.001
|
Audience |
Internationale
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Domaine(s) |
|
Mots-clés |
en
PPNB, Domestication, Paleopathology of tuberculosis, Early Neolithic, Lipid biomarkers, Ancient DNA, Agriculture cradle
|
DOI | 10.1016/j.tube.2015.02.001 |
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Baker_et_al_Human_tuberculosis_predates_domestication_ancient_Syria_Tuberculosis_2015.pdf ( 2.62 Mo
)
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