O. Articles and . Et-chapitres-d'ouvrages,

P. Abecassis and N. Coutinet, Caractéristiques du Marché des Médicaments et Stratégies des Firmes Pharmaceutiques », Horizon Stratégiques, vol.7, pp.janvier-mars, 2008.

R. Acharya and W. Keller, National Bureau of Economic Research Working Paper, 2007.

P. Aghion and P. Howitt, A model of growth through creative destruction, Econometrica, vol.60, issue.2, pp.323-351, 1992.

P. Aghion and P. Howitt, « Théorie de la croissance endogène, 2000.

J. Aizenman, Exchange rate flexibility, volatility and domestic and foreign direct investment, 1992.

B. B. Allred and W. G. Park, The Influence of Patent Protection on Firm Innovation Investment in Manufacturing Industries, Journal of International Management, vol.13, pp.91-109, 2007.

B. Amable, Systèmes d'innovation, 2003.

«. De, Economica, p.749

B. Amable, R. Barré, and R. Boyer, « Les systèmes d'innovation à l'ère de la globalisation, Economica, 1997.

B. Anand and T. Khanna, The structure of licensing contracts, Journal of Industrial Economics, vol.48, issue.1, pp.103-135, 2000.

E. Andersen and B. A. Lundvall, National innovation systems and the dynamics of the division of labor, Systems of Innovation: Technologies, Institutions and Organizations, pp.242-265, 1997.

W. Andreff, Les multinationales globales, 1996.
URL : https://hal.archives-ouvertes.fr/halshs-00275225

M. Angell, La vérité sur les compagnies pharmaceutiques -Comment elles nous trompent et comment les contrecarrer », Ed. Les Mieux-être, p.320, 2005.

P. Antomarchi, Les barrières à l'entrée en économie industrielle », L'Harmattan, p.188, 1998.

C. Antonelli, Models of knowledge and systems of governance, Journal of Institutional Economics, vol.1, pp.51-73, 2005.

S. Aouadi, Le rendement de l'investissement dans la Recherchedéveloppement: approche méthodologique et illustration empirique en Tunisie, dans les pays arabes et dans le monde, p.20, 2003.

Y. Arnoux, Les Entreprises du M2dicaments, Biotechnologies, 2005.

A. Arora and A. Gambardella, Complementarity and External Linkages: the Strategies of the Large Firms in Biotechnology, Journal of Industrial Economics, vol.38, pp.361-379, 1990.

A. Arora and R. Merges, Specialized supply firms, property rights and firms' boundaries, pp.451-475, 2003.

A. Arora, A. Fosturi, and A. Gambardella, Markets for Technology: the Economics of Innovation and Corporate Strategy, 2001.

K. J. Arrow, The Rate and Direction of Inventive Activity: Economic and Social Factors, 1962.

S. Arvanitis and H. Hollenstein, European Data Watch: Firm Panel Data from the Swiss Innovation Survey, Journal of Applied Social Science, vol.124, issue.2, pp.305-314, 2004.

B. Asheim and M. Gertler, Understanding regional innovation systems, Handbook of Innovation, 2004.

B. T. Asheim and A. Isaksen, Regional innovation systems: the integration of local 'Sticky' and global 'ubiquitous' knowledge, Journal of Technology Transfer, vol.27, pp.77-86, 2002.

E. Asiedu, On the determinants of foreign direct investment to developing countries: Is Africa Different?, World Development, vol.30, pp.1107-119, 2002.

E. Atukeren, Interactions between Public and Private Investment: Evidence from Developing Countries, 2004.

F. Ayachi and C. Berthomieu, «Les déterminants des investissements directs étrangers européens et la gouvernance dans la région MEDA: une estimation par la méthode des moments généralisés», pp.26-27, 2006.

R. Azzouna and R. Hamdane, Décret du 15 juin 1888, premier décret réglementant l'exercice de la pharmacie en Tunisie, et évolution de la législation pharmaceutique avant et après l'indépendance », Revue d, Histoire de la Pharmacie, vol.54, pp.479-496, 2007.

J. Bain, Barriers to New Competition, 1956.

J. B. Barney, Organizational culture: can it be a source of sustained competitive advantage?, Academy of Management Review, vol.11, issue.3, pp.656-665, 1986.

M. J. Bates, Information and Knowledge: An Evolutionary Framework for Information Science, Information Research, 2005.

A. Bedoui, « L'ajustement structurel et ses effets sur l'économie tunisienne », International Network of Engineers and Scientists for global Responsibility (INES), 1996.

M. Ben-romdhane, Commerce et Stratégies de Développement. Cas de la Tunisie, vol.53, 2007.

C. Benlakhdar and M. Foucault, Brevets et innovation: une comparaison transatlantique, La Revue Internationale et Stratégique, N°55, 2004.

J. Benoit, Innovation and Imitation in a Duopoly, Review of Economic Studies, vol.52, issue.1, pp.99-106, 1985.

J. Bentham, A Manual of Political Economy, MSS, 1843.

H. R. Bernard, Social Research Methods: Qualitative and Quantitative Approaches, p.659, 2000.

E. R. Berndt, D. Ling, and M. K. Kyle, The Long Shadow of Patent Expiration: Generic Entry and Rx-to-OTC Switches, NBER Studies on income and Wealth, pp.229-273, 2003.

E. Berthet-maillols, Brevet, CCP et Protection des données de l'AMM, 2008.

J. C. Billaut, D. Bouyssou, and P. Vincke, « Faut-il croire le classement de Shanghai ? Une approche fondée sur l'aide multicritère à la décision », Revue de la Régulation, Institutions, 2010.

D. J. Birkett, Generics -Equal or Not?, Australian Prescriber, vol.26, 2003.

M. J. Bizet, Les ADPIC et la santé publique, 2003.

A. Blanchet, L'enquête et ses méthodes, l'entretien, 125p, 1995.

A. Blanchet and A. Gotman, L'enquête et ses méthodes, l'entretien, 1992.

M. I. Blejer and M. S. Khan, Government policy and private investment in developing countries, 1984.

M. Blomström and A. Kokko, Multinational Corporation and Spillovers, Journal of Economic Surveys, vol.12, issue.3, pp.247-277, 1998.

B. A. Blonigen, A Review of the Empirical Literature on FDI Determinants, p.11299, 2005.

B. Boidin and L. Lesaffre, Droits de la propriété Intellectuelle, Partenariats entre Firmes Pharmaceutiques et Accès des Pays Pauvres aux Médicaments, pp.1049-1075, 2009.

M. Boldrin and D. K. Levine, Against intellectual property monopoly, 2008.

R. Bondt, Spillovers and innovative activities, International Journal of Industrial Organization, issue.de, pp.1-28, 1996.

H. Bouklia and N. Et-zatla, «L'IDE dans le bassin méditerranéen, ses déterminants et son effet sur la croissance», FEMISE network, 2001.

R. Boyer and M. Didier, « Innovation et croissance: relancer une dynamique de croissance durable par l'innovation », Innovation et Croissance, La Documentation Française, 1998.

L. Brainard, A Simple Theory of Multinational Corporations and Trade with a Trade-off between Proximity and Concentration, NBER Working Paper, p.4269, 1993.

L. G. Branstetter, R. Fisman, and C. F. Foley, Do Stronger Intellectual Property Rights Increase International Technology Transfer? Empirical Evidence from U.S. Firm-Level Panel Data, 2003.

S. Breschi and F. Malerba, Sectoral innovation systems, technological regimes, Schumpeterian dynamics and spatial boundaries, Systems of Innovation: Technologies, Institutions and Organizations, pp.130-156, 1997.

E. Brubaker, « Free ride, free revelation, or golden rule, Journal of Law and Economics, vol.18, pp.147-161, 1975.

J. M. Buchanan, « Politics, Policy, and the Pigovian Margins, pp.17-28, 1962.

J. M. Buchanan and M. E. Flowers, The Public Finances: An Introductory Textbook, 1975.

P. Buckley and M. Casson, The Future of the Multinational Enterprise, Homes & Meier, 1976.

J. Caccomo, « L'épopée de l'innovation : Innovation technologique et évolution économique, p.148, 2005.

T. Caliari and R. Ruiz, Brazilian pharmaceutical industry and generic drugs: the political intentions and the unexpected changes, 2010.

M. Callon, R. Boyer, B. Chavanne, and O. Godar, Réseau technico-économiques et irréversibilités, 1991.

B. Carlsson, S. Jacobsson, M. Holmen, and A. Rickne, Innovation systems: analytical and methodological issues, Research Policy, N°32, pp.233-245, 2002.

D. Canning, M. Fay, and R. Perotti, International Differences in Growth Rates, 1994.

H. Capron and M. Cincera, Management of Technology: The Key to Prosperity in the Third Millenium, pp.207-222, 2001.

P. Caracostas and L. Soete, The building of cross-border institutions in Europe: Towards a European system of innovation?, Systems of Innovation: Technologies, Institutions and Organizations, pp.395-419, 1997.

E. G. Carayannis and M. Provance, Measuring firm's innovativeness: towards a composite innovation index built on firm innovative posture, propensity and performance attributes, International Journal of Innovation and Regional Development, vol.1, issue.1, pp.90-107, 2008.

J. Carlino, Knowledge spillovers: the cities' role in the new economy, Business Review, vol.4, pp.17-26, 2001.

B. Carlsson and R. Stankiewicz, On the nature, function and composition of technological systems, Journal of Evolutionary Economics, vol.1, pp.93-118, 1991.

D. Carré and N. Levratto, Dynamique des territoires, agglomération et localisation des firmes, pp.183-206, 2011.

A. P. Carter, Know-how trading as economic exchange, Research Policy, vol.18, pp.1-9, 1989.

V. Casadella and M. Benlahcen-tlemcani, De l'applicabilité du système national d'innovation dans les pays moins avancés, pp.59-90, 2006.

M. Cassier and M. Correa, Patents, innovation and public health: Brazilian public sector laboratories' experience in copying AIDS drugs, Economics of AIDS and Access to HIV/AIDS Care in Developing Countries. Issues and Challenge, pp.89-107, 2003.
URL : https://hal.archives-ouvertes.fr/halshs-00849013

M. Cassier and M. Correa, « Brevets de médicament, luttes pour l'accès et intérêt public au Brésil et en Inde », Innovations, Cahiers d'Economie de l'Innovation, vol.32, pp.109-127, 2010.

R. Caves, Causes of direct investment: Foreign firms shares in Canadian and United Kingdom manufacturing industries, Review of Economics and Statistics, vol.56, pp.279-293, 1974.

R. Caves, Economic Analysis and the quest for Competitive advantage, American Economic Review, vol.74, pp.127-136, 1984.

L. Cecchini, Déterminants des IDE dans les pays du bassin méditerranéen», Communication au Colloque de l'université de printemps des économies méditerranéennes et du monde arabe, 2002.

S. Chadhuri, P. K. Goldberg, and P. Jia, the effects of extending intellectual property rights protection to developing countries: a case study of the Indian pharmaceutical market, 2003.

A. Chakrabarti, The determinant of foreign direct investment: Sensitivity analyses of cross-country regressions, Kyklos, vol.54, pp.114-189, 2001.

A. Chavanne and J. Burst, Droit de la Propriété Industrielle, 1998.

Y. Chen and T. Puttitanun, Intellectual property rights and innovation in developing countries, Journal of Development Economics, issue.78, pp.474-493, 2005.

L. K. Cheng and Y. K. Kwan, What are the determinants of the location of foreign direct investment? The Chinese experience, Journal of International Economics, pp.370-400, 2000.

H. Chesbrough, The era of open innovation, MIT Sloan Management Review, vol.44, issue.3, pp.35-41, 2003.

H. Chesbrough, Open Innovation: The New Imperative for Creating and Profiting from Technology, 2003.

H. Chesbrough, Open Business Models: How to Thrive in the New Innovation Landscape, 2006.

R. Chittoor, S. Ray, P. Aulakh, and M. Sarkar, Strategic responses to institutional changes: 'Indigenous growth' model of the Indian pharmaceutical industry, Journal of International Management, issue.14, pp.252-269, 2008.

J. P. Choi, Patent litigation as an information-transmission mechanism, American Economic Review, issue.88, 1998.

F. Chrétien, J. Smets, and B. Et-warusfel, Les Enjeux de la Propriété Intellectuelle en Europe, Groupe des Belles Fleurs, 2003.

E. Christen-gueissaz, Recherche-action : Processus d'apprentissage et d'innovation sociale », L'Harmattan, p.236, 2006.

C. Clift, Research Handbook on the Protection of Intellectual Property Rights under the WTO Rules, Why IPR issues were brought to GATT: A historical perspective on the origin of TRIPS, pp.3-21, 2010.

R. Coase, The problem of social cost, Journal of Law and Economics, vol.3, 1960.

R. Coase, The Lighthouse in economics, Journal of Law and Economics, pp.357-376, 1974.

R. Coase, The Firm, the Market and the Law, 1988.

I. Cockburn, Is the Pharmaceutical Industry in a Productivity Crisis?, 2006.

I. M. Cockburn and R. M. Henderson, Publicly Funded Science and the Productivity of the Pharmaceutical Industry, National Bureau of Economic Research, vol.1, pp.20-21, 2000.

D. T. Coe and E. Helpman, International R&D Spillovers, NBER Working Papers, 1995.

W. M. Cohen and D. A. Levinthal, Absorptive capacity: a new perspective on learning and innovation, Administrative Science Quarterly, issue.35, pp.128-152, 1990.

W. M. Cohen and D. A. Levinthal, Innovation and learning: The two faces of R&D, The Economic Journal, vol.99, issue.397, pp.569-596, 1989.

W. M. Cohen, R. Nelson, and J. Walsh, Protecting their intellectual assets : appropriability conditions and why firms patent or not?, 2000.

E. Combe and E. Pfister, Le renforcement international des droits de propriété intellectuelle, Economie Internationale, La Revue du CEPII, vol.85, pp.63-81, 2001.

E. Combe and H. Haug, Les laboratoires pharmaceutiques face à la concurrence des génériques : Quels enjeux pour l'antitrust ? », Concurrences, pp.47-62, 2006.

F. Contractor, International technology licensing: Compensation, Costs and Negotiations, 1981.

P. Cooke, New economy innovation systems: biotechnology in Europe and the USA, Industry and Innovation, vol.3, pp.267-289, 2001.

R. Coombs, P. Narandren, and A. Richards, A literature-based innovation output indicator, Research Policy, vol.25, issue.4, pp.403-413, 1996.

B. Coriat, Le nouveau régime américain de la propriété intellectuelle, contours et caractéristiques clés », Revue d'Economie Industrielle, p.99, 2002.

B. Coriat, The Political Economy of HIV/AIDS in Developing Countries, 2008.

B. Coriat and O. Weinstein, Organizations, firms and institutions in the generation of innovation, Research Policy, vol.31, issue.2, pp.273-290, 2002.

B. Coriat and F. Orsi, Brevets pharmaceutiques, génériques et santé publique. Le cas de l'accès aux traitements antirétroviraux, vol.12, pp.153-177, 2003.

R. Cowan, S. Breschi, and F. Malerba, Network Models of Innovation and Knowledge Diffusion, Clusters, Networks and Innovation, 2005.

T. Cowen, Public Goods and Market Failures: A Critical Examination, 1999.

C. Crampes and C. Langinier, Litigation and settlement in patent infringement cases, RAND Journal of Economics, issue.33, 2002.

D. O. Cushman, Real exchange rate risk, expectations and the level of direct investment, The Review of Economics and Statistics, vol.67, issue.2, pp.297-308, 1985.

D. O. Cushman, The effects of real wages and labor productivity on foreign direct investment, Southern Economic Journal, vol.54, issue.1, pp.174-85, 1987.

F. Damanpour, Organizational innovation: a meta-analysis of effects of determinants and moderators, Academy of Management Journal, vol.34, issue.3, pp.555-590, 1991.

D. A. Daniel, The nightmare of the pharmaceutical industry in Brazil, WIPO, 0199.

P. David, B. Hall, and A. Toole, Is public R&D a complement or a substitute for private R&D? A review of the econometric evidence, Research Policy, vol.29, pp.497-529, 2000.

P. David and J. Rosenbloom, Marshallian factor market externalities and dynamics of industrial localization, Journal of Urban Economics, vol.28, pp.349-370, 1990.

J. Davis, From penicillin to Viagra -A century of achievement, pp.37-40, 2000.

D. Deberdt, Statistiques sur le Brevets Européen, 2005.

C. Deere-birkbeck, Developing countries in the global IP system before TRIPS: the political context for the TRIPS negotiations, pp.22-51, 2010.

C. Delvoie, « Le monde tunisien visité par la banque mondiale, Revue I.E.A. No, vol.293, pp.juillet-août, 1999.

H. Demsetz, The private production of public goods, Journal of Law and Economics, vol.13, pp.293-306, 1970.

V. Denicolo and L. A. Franzoni, The contract theory of patent, International Review of Law and Economics, vol.23, issue.4, pp.365-380, 2003.

M. H. Depret and A. Hamdouch, Droits de Propriété Intellectuelle, Orientation de la R&D Pharmaceutique et Accès aux Soins dans les Pays en Développement, Séminaire « Institutions et Développement, 2004.

J. A. Dimasi, R. W. Hansen, and H. G. Grabowski, The price of innovation: new estimates of drug development costs, Journal of Health Economics, issue.22, pp.151-185, 2003.

G. B. Dinwoodie and R. Dreyfuss, Enhancing global innovation policy: the role of WIPO and its Conventions in interpreting the TRIPS Agreement, pp.110-145, 2010.

A. Djeflat, Construction des systèmes d'innovation en phase de décollage dans les pays Africains: essai d'analyse à partir des centres techniques industriels au Maghreb, p.23, 2009.

A. Djeflat, Building innovation systems in developing countries: issues and prospects, Globelics Academy PhD School, 2011.

M. Dodgson, Organizational learning: a review of some literatures, Organization Studies, vol.14, pp.375-394, 1993.

D. Doloreux, Regional innovation systems in the periphery: The case of the Beauce in Québec (Canada), International Journal of Innovation Management, vol.7, issue.1, pp.67-94, 2003.

D. Doloreux and S. Parto, Regional innovation systems: a critical review, ERSA Conference papers, p.26, 2004.

E. Domar, Expansion and employment, American Economic Review, vol.37, issue.1, pp.34-55, 1947.

G. Dosi, G. Dosi, C. Freeman, and R. Nelson, The Nature of Innovation Process, Technical Change and Economic Theory, 1982.

G. Dosi and M. Egidi, « Substantive and procedural uncertainty. An exploration of economic behaviours in changing environments, Journal of Evolutionary Economics, vol.1, issue.1, pp.145-168, 1991.

J. C. Dousset, Histoire des médicaments des origines à nos jours, 1985.

G. Duflos and E. Pfister, Les Déterminants des Fusions-Acquisitions. Cas de l'Industrie Pharmaceutique », Marchés, vol.58, pp.577-586, 2007.

E. Duguet and C. Lelarge, Les Brevets incitent-ils les entreprises à innover ?, Economie et Statistiques, N°380, pp.35-61, 2004.

J. H. Dunning, Reappraising the eclectic paradigm in the age of alliance capitalism, Journal of International Business Studies, issue.26, pp.461-491, 1995.

J. H. Dunning, Towards an eclectic theory of international production: some empirical tests, Journal of International Business Studies, vol.11, issue.1, pp.9-31, 1980.

S. Dupuch and C. Milan, Les déterminants des investissements directs européens dans les pays d'Europe Centrale et Orientale », L'Actualité économique, vol.81, pp.521-534, 2005.

L. Earl and F. Gault, National Innovation Indicators and Policy, 2006.

J. Eaton and S. Kortum, Technology, Geography, and Trade, vol.70, issue.5, pp.1741-1779, 2002.

C. Edquist, Systems of Innovation: Technologies, Institutions and Organizations, 1997.

R. S. Eisenberg, Patents and data-sharing in public science, Industrial and Corporate Change, vol.15, pp.1013-1031, 2006.

L. El-kateb, , pp.16-20, 2005.

J. Estrin, Reigniting the Spark of Creativity in a Global Economy, p.272, 2008.

H. Etkowitz and L. Leydersdorff, « The dynamics of innovation: from national systems and 'mode 2' to a triple helix of university-industry-government relations, Research Policy, vol.29, pp.109-123, 2000.

F. M. Fai, Using intellectual property data to analyse China's growing technological capabilities, pp.49-61, 2005.

M. H. Fallah and S. Ibrahim, Knowledge spillovers and innovation in technological clusters, Proceedings, IAMOT, 2004.

A. Fayolle, A. Ben-salah, I. Ben-salah, and L. Belkacem, Efficacité des pépinières dans la création d'entreprise innovante : cas de la Tunisie, pp.157-179, 2010.

S. Feeny and M. Rogers, Innovation and performance: benchmarking Australian firms, Australian Economic Review, vol.36, issue.3, pp.253-264, 2003.

C. Feldman, The Geography of Innovation, 1994.

H. Fenneteau, Enquête : entretien et questionnaires, Dunod, p.126, 2002.

M. J. Ferrantino, The effect of intellectual property rights on international trade and investment, Weltwirtschaftliches Archiv, vol.129, pp.300-331, 1993.

C. Fink, How stronger patent protection in India might affect the behavior of transnational pharmaceutical industries?, 2000.

C. Fink and C. A. Primo-braga, The Relationship between Intellectual Property Rights and Foreign Direct Investment, Duke Journal of Comparative and International Law, vol.9, pp.163-188, 1998.

M. M. Fischer, Innovation, knowledge creation and systems of innovation, The Annals of Regional Science, vol.35, issue.2, pp.199-216, 2000.

D. Foray, The knowledge economy and society, International Social Science Journal, vol.54, issue.71, pp.1-169, 2002.

D. Foray, « L'économie de la connaissance, 2009.

C. Forero-pineda, The Impact of Stronger Intellectual Property Rights on Science and Technology in Developing Countries, Research Policy, vol.35, pp.808-824, 2006.

F. Fort, J. Rastoin, and L. Et-temri, Les déterminants de l'innovation dans les petites et moyennes entreprises agroalimentaires, vol.18, pp.47-72, 2005.

A. Fosfuri, M. Motta, and T. Ronde, Foreign direct investment and spillovers through workers mobility, Journal of International Economics, vol.53, issue.1, pp.205-222, 2001.

A. Fosfuri, Patent Protection, Imitation and the Mode of Technology Transfer, International Journal of Industrial Organization, vol.18, pp.1129-1149, 2000.

C. Freeman, Technology and Economic Performance: Lessons from Japan, 1987.

C. Freeman, Continental, National and Sub-National Innovation SystemsComplementarity and Economic Growth, Research Policy, vol.31, issue.2, pp.191-211, 2002.

C. Freeman, The national system of innovation in historical perspective, Cambridge Journal of Economics, vol.19, issue.1, pp.5-24, 1995.

D. Friedman, « Vers une société sans Etat », traduction de l'édition américaine de 1973, Les Belles Lettres, 1992.

J. Fuguet, B. Guilhon, and F. Tellissi, « Institutions et Dynamique de l'Industrie Pharmaceutique en Tunisie », Communication au Colloque Mondialisation, Institutions et Systèmes productifs aux pays du Maghreb, Organisé par PS2D, Prospectives, Stratégies et Développement Durable, 2006.

V. Fuster and J. M. Sweeny, Aspirin: A historical and contemporary therapeutic overview, Circulation, issue.123, pp.768-778, 2011.

M. A. Gagnon and J. Et-lexchin, The Cost of Pushing Pills: A New Estimate of Pharmaceutical Promotion Expenditures in the United States, PLoS Med Review, vol.5, issue.1, 2008.

,

J. Galbraith, Pour une société meilleure : Un programme pour l'humanité, 1997.

A. Galliano, Pfizer se Renforce dans les Génériques, 2009.

N. Gallini, The economics of patents: lessons from recent U.S. patent reform, Journal of Economic Perspectives, p.16, 2002.

N. Gallini and S. Scotchmer, Intellectual property: when is it the best incentive mechanism?, pp.51-77, 2002.

N. T. Gallini, Patent Policy and Costly Imitation, RAND Journal of Economics, vol.23, issue.1, pp.52-63, 1992.

N. T. Gallini, The economics of patents. Lessons from recent U.S. patent reform, Journal of Economic Perspectives, vol.16, issue.2, pp.131-154, 2002.

A. Gambardella, P. Giuri, and A. Luzzi, The market for patents in Europe, 2006.

A. Gambardella, Science and Innovation: The U.S. Pharmaceutical Industry during the 1980s, 1995.

B. Gaumer, L'organisation Sanitaire en Tunisie sous le Protectorat Français, p.300, 2006.

D. Germidis, Development Centre of the Organization for Economic Cooperation and Development, 1977.

M. Gertler, Whither monetary and financial stability? The implications of evolving policy regimes: commentary, pp.213-223, 2003.

F. Ghozali, Industrie Pharmaceutique en Tunisie : Cap sur l'Export », Dossier Spécial Tunisie, Jeune Afrique, pp.2502-2503, 2009.

M. Gibbons, C. Limoges, H. Nowotny, S. Schwartzman, P. Scott et al., The New Production of Knowledge: The Dynamics of Science and Research in Contemporary Societies, 1994.

R. J. Gilbert and D. M. Newberry, Preemptive Patenting and the Persistence of Monopoly, p.464, 1982.

J. Ginarte and W. G. Park, Intellectual property rights and economic growth, Contemporary Economic Policy, vol.15, pp.51-61, 1997.

E. L. Glaeser, H. D. Kallal, J. A. Scheinkman, and A. Shleifer, Growth in cities, Journal of Political Economy, vol.100, pp.1126-1152, 1992.

B. Godin, National innovation system: The system approach in historical perspective, Project on the history and sociology of STI statistics, 2007.

H. G. Grabowski, Patents, Innovation and Access to New Pharmaceuticals, Journal of International Economic Law, vol.5, pp.849-860, 2002.

C. Grace, The effects of changing intellectual property on pharmaceutical industry prospects for India and China, technology transfer and access to medicine, DFID, 2004.

N. Grandfils, V. Paris, and C. Sermet, Les Laboratoires pharmaceutiques face à l'arrivée des génériques : quelles stratégies pour quels effets ? », Bulletin d'Information en Economie de la Santé, vol.84, 2004.

B. C. Greenwald and J. E. Stiglitz, Externalities in Economies with Imperfect Information and Incomplete Markets, Quarter Journal of Economics, vol.101, pp.229-230, 1986.

Z. Griliches, Issues in assessing the contribution of R&D to product growth, Bell Journal of Economics, vol.10, pp.92-116, 1979.

Z. Griliches and F. Lichtenberg, Interindustry technology flows and productivity growth: A re-examination, The Review of Economics and Statistics, issue.65, pp.324-329, 1984.

G. Grossman and E. Helpman, Endogenous innovation in the theory of growth, Journal of Economic Perspectives, vol.8, pp.23-44, 1994.

D. Guellec, Economie de l'innovation, 1999.

S. Guennif and C. Mfuka, Brevets et santé dans les PED, 2003.

B. Guillochon and A. Kawecki, Economie internationale, commerce et macroéconomie, 2003.

M. Guir and R. Crener, « L'investissement direct et la firme multinationale, p.186, 1984.

S. Haddad, Etat des lieux », Innovations, Cahiers d'Economie de l'Innovation, Institutions et politiques publiques de soutien du système d'innovation en Tunisie, vol.33, pp.137-156, 2010.

J. Hagedoorn and M. Cloodt, Measuring innovative performance: is there an advantage in using multiple indicators?, Research Policy, vol.32, issue.8, pp.1365-1379, 2003.

H. Håkansson, Corporate Technological Behaviour, 1989.

L. Hakmi and H. Zaoual, « La dimension territoriale de l'innovation », Marchés et Innovation, N°7, Développement Durable des territoires, p.31, 2008.

B. Hall and J. Van-reenen, « How effective are fiscal incentives for R&D? A review of the evidence, Research Policy, vol.29, pp.449-469, 2000.

N. Halpern, L'Innovation Thérapeutiques des Nouveaux Médicaments en Question », Les Echos, N°18325, 2001.

A. Hamdouch and H. Feng, R&D offshoring and clustering dynamics in pharmaceuticals and biotechnology: key features and insights from the chinese case, Journal of Innovation Economics, issue.2, pp.95-117, 2009.

A. Hamdouch, The collective innovation process and the need for dynamic coordination. General Presentation, Journal of Innovation Economics, vol.2, pp.3-13, 2008.

A. Hamdouch and M. Depret, La Nouvelle Economie Industrielle de la Pharmacie : Structures Industrielles, Dynamique d'Innovation et Stratégies Commerciales », Editions Scientifiques et Médicales Elsevier SAS Paris, p.296, 2001.

A. Hamdouch and M. Depret, Coalitions industrielles, réseaux de firmes et dynamiques de concurrence-coopération dans les secteurs en cours de globalisation : le cas de l'industrie pharmaceutique », Cahiers de la MSE, Série Rouge, pp.2000-2024, 2000.

R. Harrod, Towards a Dynamic Economics, 1948.

R. F. Harrod, An essay in dynamic theory, The Economic Journal, vol.49, issue.193, pp.14-33, 1939.

M. Hasper, Intellectual property rights protections in developing countries: the effect of TRIPs on the production and dissemination of cures specific to developing country diseases, p.63, 2005.

N. Hatch and J. Dyer, Human capital and learning as a source of sustainable competitive advantage, Strategic Management Journal, vol.25, pp.1155-1178, 2004.

F. A. Hayek, The use of knowledge in society, American Economic Review, vol.35, pp.519-530, 1945.

J. G. Head, Public Goods and Public Policy, pp.197-219, 1962.

J. G. Head and C. S. Shoup, Public Good, Private Good and Ambiguous Goods, Economic Journal, issue.79, p.567, 1969.

M. Heller and R. Eisenberg, Can patent deter innovation? The anticommons in biomedical research, Science, vol.280, pp.698-701, 1998.

E. Helpman, Innovation, Imitation and Intellectual Property Rights, Econometrica, vol.61, pp.1247-1280, 1993.

P. Hertog and E. Brouwer, Innovation indicators for the retailing industry: a meso perspective, 2000.

B. Hoekman and B. Javorcik, Global Integration and Technology Transfer, 2006.

H. Hollander and F. C. Esser, Measuring innovation efficiency, 2007.

H. Hollenstein, A Composite indicator of a firm's innovativeness. An empirical analysis based on survey data for Swiss manufacturing, Research Policy, vol.25, pp.633-645, 1996.

D. F. Horrobin, Glittering prizes for research support, Nature, issue.324, p.221, 1986.

A. W. Horwitz and E. L. Lai, Patent Length and the Rate of Innovation, International Economic Review, vol.37, issue.4, pp.785-801, 1996.

P. Howitt, Endogenous Growth, Productivity and Economic Policy: A Progress Report, pp.3-15, 2004.

Y. Huang and T. Khanna, Can India overtake China?, Foreign Policy, pp.74-81, 2003.

J. G. Hummel, National Goods Versus Public Goods: Defence, Disarmament, and Free Riders, The Review of Austrian Economics, vol.4, pp.88-122, 1990.

P. L. Hunsaker and M. W. Coombs, Mergers and acquisitions: managing the emotional issues, Personnel, issue.67, pp.56-63, 1988.

J. Jacobs, The Economy of Cities, 1961.

D. Jacobson, Aspects of industrial policy, The Mc-Grow-Hill book Companies, 1997.

A. Jaffe, R. Newell, and R. N. Stavins, A tale of two market failures. Technology and environmental policy, Ecological Economics, issue.54, pp.164-174, 2004.

T. Jefferson, Letter to Isaac McPherson Monticello, p.1813, 1813.

B. Johnson, B. Lundvall, M. Muchie, P. Gammerltoft, and B. Lundvall, Putting Africa First: the making of African Innovation Systems, pp.13-29, 2003.

H. N. Joshi, Analysis of the Indian pharmaceutical industry with emphasis on opportunities of, Pharmaceutical Technology, 2003.

J. P. Juès, « L'industrie pharmaceutique », PUF, Paris, collection « que saisje ?, p.3276, 1998.

U. Kaiser, Measuring knowledge spillovers in manufacturing and services: an empirical assessment of alternative approaches, Research Policy, issue.31, pp.125-169, 2002.

N. Kaldor, A model of economic growth, The Economic Journal, vol.67, issue.268, pp.591-624, 1957.

M. I. Kamien, E. Muller, and I. Zang, Research joint ventures and R&D cartels, The American Economic Review, issue.82, pp.1293-1306, 1992.

M. Kelly and A. Hageman, Marshallian externalities in innovation, Journal of Economic Growth, vol.4, p.39, 1999.

J. M. Keynes, The general theory of employment, The Collected Writings, vol.14, 1937.

T. Kirat and Y. Lung, Innovation and proximity: territories as loci of collective learning processes, European Urban and Regional Studies, vol.6, issue.1, pp.27-38, 1999.

E. W. Kitch, The nature and function of the patent system, The Journal of Law and Economics, vol.20, 1977.

P. Klemperer, How Broad Should the Scope of Patent Protection Be?, The RAND Journal of Economics, vol.21, pp.113-130, 1990.

S. J. Kline and N. Rosenberg, Innovation: An overview, The Positive Sum Strategy: Harnessing Technology for Economic Growth, 1986.

M. Kochen, Annual Review of Information, Science and Technology, vol.18, 1983.

B. Koo and B. D. Wright, Economics of Patenting a Research Too, 2001.

M. Kremer, Patent Buyouts: A Mechanism for Encouraging Innovation, Quarterly Journal of Economics, pp.1137-1167, 1998.

P. Krugman, Increasing returns and economic geography, Journal of Political Economics, vol.99, pp.483-499, 1991.

W. Kuemmerle, Foreign direct investment in industrial research in the pharmaceutical and electronics industries-results from a survey of multinational firms, Research Policy, vol.28, issue.2-3, p.183, 1999.

T. S. Kuhn, La structure des révolutions scientifiques, 1983.

J. Lachmann, « Financer l'innovation des PME, Economica, 1996.

E. Lai, International Intellectual Property Rights Protection and the Rate of Product Innovation, Journal of Development Economics, vol.55, issue.2, pp.133-153, 1998.

J. O. Lanjouw, A. Pakes, P. , and J. , How to count patents and value intellectual property: the uses of patent renewal and application data, Journal of Industrial Economics, vol.46, pp.405-432, 1998.

J. O. Lanjouw, The Introduction of Pharmaceutical Product Patents in India: 'Heartless Exploitation of the Poor and Suffering'?, NBER working papers series, 1998.

A. Lanouar, Tunisie : le secteur pharmaceutique, 2006.

B. Laperche, Knowledge capital' and innovation in global corporations, International Journal of Technology and Globalization, vol.3, pp.24-41, 2007.

B. Laperche, Innovation and the profitability imperative: consequences on the formation of the firm's knowledge capital, 2008.

B. Laperche, « Stratégies d'innovation des firmes des sciences de la vie et appropriation des ressources végétales: processus et enjeux, vol.147, 2009.

B. Laperche, « Potentiel d'innovation des grandes entreprises et État, argumentation évolutionniste sur l'appropriation des informations scientifiques et techniques », Innovations, Cahiers d'Economie d'Innovation, pp.61-85, 2001.

B. Laperche, De l'incitation à l'invention au contrôle de l'innovation, Propriété industrielle et innovation : la nouvelle économie fausse-t-elle l'enjeu ? », L'Harmattan, Collection Economie et Innovation, 2001.

B. Laperche, La propriété industrielle, moteur ou frein à l'innovation ?, pp.63-84, 2004.

B. Laperche, « Les inventions, la science et la guerre : la place du secret, Innovations, vol.1, 2005.

B. Laperche, How to coordinate the networked enterprise in a context of open innovation? A new function for intellectual property rights, Journal of the Knowledge Economy, 2011.

B. Laperche and D. Uzunidis, « Le système national d'innovation russe en restructuration, Réformes institutionnelles et politique industrielle », Innovations, Cahiers d'économie de l'innovation, vol.26, pp.69-94, 2007.

B. Laperche and D. Uzunidis, Crise, innovation et renouveau des territoires : dépendance de sentier et trajectoires d'évolution, pp.159-182, 2011.

B. Laperche, G. Lefebvre, and D. Langlet, Innovation strategies of industrial groups in the global crisis: rationalization and new paths, Technological Forecasting and Social Change, vol.78, issue.8, pp.1319-1331, 2011.

B. Laperche, D. Uzunidis, and G. N. Von-tunzelmann, The Genesis of Innovation. Systemic Linkages between Knowledge and the Market, 2008.

N. Lazaric, Éditions La Découverte/collection Repères, p.128, 2010.

L. Bas and C. , « Fonctionnement, transformation et tensions du système international de brevet. Les implications du 'cours pro-brevet' à la lumière des études empiriques récentes, Revue D'Economie Industrielle, vol.99, pp.249-266, 2002.

, De la recherche à la l'AMM. Pourquoi les brevets ? », Les Entreprises du Médicament, article publié le 03 Mai, 2006.

, Les Biosimilaires », Les Entreprises du Médicament, 2008.

, « Les grandes étapes de la vie du médicament. Naissance et vie du médicament, Les Entreprises du Médicament, article publié le 05 Mai, 2011.

A. Léger, Intellectual Property Rights and Innovation in Developing Countries: Evidence from Panel Data, Proceedings of the German Development Economics Conference, 2006.

G. Legrand and H. Martini, Management des opérations de commerce international, Dunod, 2003.

W. Lesser, The effects of TRIPS mandated intellectual property rights on economic activities in developing countries, 2000.

F. Lévêque, Droit de la concurrence et innovation », Séminaire Ressources et Technologiques et Innovations, 2006.

F. Lévêque and Y. Ménière, The Economics of Patents and Copyright, 2004.

F. Lévêque and Y. Ménière, Patent and innovation: Friends or foes?, 2006.

R. C. Levin and P. C. Reiss, Cost-reducing and demand-creating R&D with spillovers, Rand Journal of Economics, vol.19, pp.538-56, 1988.

. Li, Research Handbook on the Protection of Intellectual Property Rights under the WTO Rules, TRIPS-plus-plus initiatives on broad border measures: features and implications, pp.24-47, 2010.

M. Libermann, The learning curve and pricing in the chemical processing industries, The Rand Journal of. Economics, vol.15, issue.2, pp.213-228, 1984.

D. Lippoldt and W. G. Park, The impact of trade-related intellectual property rights on trade and foreign direct investment in developing countries, OECD Working Papers: Special Issue on Trade Policy, vol.4, p.11, 2003.

D. C. Lippoldt and W. G. Park, Technology Transfer and the Economic Implications of the Strengthening of Intellectual Property Rights in Developing Countries, 2008.

F. List, Système national d'économie politique, 1841.

A. Lopez, Innovation and appropriability, empirical evidence and research agenda, WIPO publications, chapter, 2008.

J. H. Lorenzi and J. L. Truel, « Se diversifier par la stratégie des filières », L'expansion, pp.98-107, 1981.

B. Los and B. Verspagen, R&D spillovers and productivity: Evidence from U.S. manufacturing microdata, Empirical Economics, vol.25, issue.1, pp.127-148, 2000.

R. E. Lucas, On the mechanics of economic development, Journal of Monetary Economics, vol.22, pp.3-42, 1988.

B. A. Lundvall, National Systems of Innovation: Towards a Theory of Innovation and Interactive Learning, 2007.

B. A. Lundvall, Innovation systems and economic development, Globelics Academy PhD School, 2011.

B. Lundvall and S. Borras, The Globalizing Learning Economy: Implications for Innovation Policy, 1997.

B. Lundvall, Product innovation and user-producer interaction, industrial development, Research Series, vol.31, 1985.

B. Lundvall, National Systems of Innovation: Towards a Theory of Innovation and Interactive Learning, 1992.

B. Lundvall, B. Johnson, E. S. Andersen, and B. Dalum, National systems of production, innovation and competence building, Research Policy, vol.31, issue.2, pp.213-231, 2002.

F. Machlup and E. Penrose, The Patent controversy in the nineteenth century, Journal of Economic History, vol.10, pp.1-29, 1950.

B. Madeuf, « Les multinationales, 0190.

F. Malerba, « Sectoral systems of innovation and production, Research Policy, issue.31, pp.247-264, 2002.

F. Malerba, Sectoral systems of innovation and technology policy, vol.2, pp.329-375, 2003.

F. Malerba, « Sectoral systems of innovation: a framework for linking innovation to the knowledge base, structure and dynamics of sectors, Economics of Innovation and New Technology, issue.14, pp.63-82, 2005.

A. Malmberg and P. Maskell, Towards an explanation of regional specialization and industrial agglomeration, European Planning Studies, vol.5, issue.1, pp.25-41, 1997.

Y. Mamou and . ;-«-le-mopral, Médicament le plus Vendu en France va Devenir un Générique, pp.13-17, 2004.

Y. Mamou and . Le-monde, Bruxelles veut faire rendre Gorge aux Laboratoires, 2008.

V. Mangematin and L. Nesta, What kind of knowledge can a firm absorb?, International Journal of Technology Management, issue.18, pp.149-172, 1999.

S. Mani, The sectoral system of innovation of Indian pharmaceutical industry, 2005.

S. Mani, Measuring innovation in a developing country context, Globelics Academy PhD School, 2011.

E. Mansfield, Research and Innovation in the Modern Corporation, 1971.

E. Mansfield, Patents and Innovation, Management and Science, vol.32, pp.173-181, 1986.

J. G. March, Exploration and Exploitation in Organizational Learning, Organization Science, vol.2, pp.71-87, 1991.

J. Markusen, Multinational Firms and the Theory of International Trade, 2002.

A. Marshall, traduction française de la 4 ème édition (1898), « Principes d'économie politique, 1890.

A. Marshall, . ;-l'industrie, and . Le-commerce, , 1918.

K. E. Maskus, The role of intellectual property rights in encouraging foreign direct investment and technology transfer, Duke Journal of Comparative and International Law, vol.9, pp.109-161, 1998.

K. E. Maskus, The WTO, intellectual property rights and the knowledge economy, World Patent Information, vol.27, p.257, 2004.

K. E. Maskus and M. Penubarti, How trade-related are intellectual property rights?, Journal of International Economics, vol.39, pp.227-248, 1995.

M. Mckeown, The Truth about Innovation, p.249, 2008.

A. B. Mehl, The Hatch-Waxman Act and market exclusivity for generic drug manufacturers: an entitlement or an incentive?, Chicago Kent Law Review, vol.81, pp.649-677, 2006.

Y. Ménière, L'accord ADPIC : 10 ans après, regards croisés Europe-Amérique du Sud », Editions Larcier, 2007.

R. Merges, Property rights, transactions, and the value of intangible assets" mimeo, 1998.

R. P. Merges and R. R. Nelson, On the Complex Economics of Patent Scope, Columbia Law Review, vol.90, issue.4, pp.839-916, 1990.

S. Meyer and T. Qu, Place-Specific Determinants of FDI The Geographical Perspective, 1995.

C. Mfuka, Accords ADPIC et brevets pharmaceutiques. le difficile accès des pays en développement aux médicaments Anti-SIDA, Revue d'Economie Industrielle, vol.99, pp.191-214, 2002.

C. A. Michalet and M. Et-delaparrière, Les implantations étrangères en France : stratégies et structures », Calmann Lévy, 1976.

E. Milbergs and N. Vonortas, White Paper of National Innovation Initiative, 21 st Century Innovation Working Group, 2005.

M. B. Miles and A. M. Huberman, Analyse des données qualitatives. Recueil de nouvelles méthodes, 2 ème Ed, 1991.

M. B. Miles and A. M. Huberman, Analyse des données qualitatives, 2003.

J. S. Mill, Principles of Political Economy, The Collected Works of John Stuart Mill, vol.3, 1848.

P. Mohnen, « Survol de la littérature sur les externalités technologiques », in, L'Évaluation Économique de la recherche et du changement technique, de Bandt, pp.97-115, 1991.

R. Morck and B. Yeung, Les Déterminants Economiques de l'Innovation, 2001.

R. Morck and B. Yeung, Les Déterminants economiques de l'innovation, 2001.

E. Moreau, . Launay, and J. Et-le-meur, « L'Industrie Pharmaceutique Indienne : De la Copie aux Génériques ? et au-delà ?, Novembre, 2004.

E. Morin, « Les Sept savoirs nécessaires à l'éducation du futur, p.129, 1999.

E. Morin, « La méthode », Points, Série Points Essais, p.271, 1999.

Y. Morvan, Fondmckeements d'économie industrielle, 1991.

G. C. Moschini, Patents and other intellectual property rights, Center for Agricultural and Rural Development, pp.1-275, 2001.

G. C. Moschini, Intellectual Property Rights and the World Trade Organization: Retrospect and Prospects, 2005.

G. J. Mossinghoff, Overview on the Hatch-Waxman Act and its Impact on the Drug Development Process, Food and Drug Law Journal, vol.54, issue.2, pp.187-194, 1999.

G. Mougenot, « Tout savoir sur le capital risque, p.330, 2002.

D. C. Mowery and N. P. Rosenberg, Technology and the Pursuit of Economic Growth, 1989.

R. Mucchielli, Le questionnaire dans l'enquête psychosociale. Connaissance du problème et applications pratiques », Les Éditions ESF (10 è éd, 1993.

R. Musgrave, The Theory of Public Finance, 1959.

M. I. Nadiri, Innovation and technological spillovers, NBER working papers series, 1993.

A. Naghavi, Strategic intellectual property rights policy and north-south technology transfer, Weltwirtschaftliches Archiv, vol.143, p.5578, 2007.

A. Nave, Marriage and the maintenance of ethnic group boundaries: the case of Mauritius, Ethnic and Racial Studies, vol.23, pp.329-352, 2000.

H. Neffati and X. Richet, « L'attractivité comparée des investissements directs étrangers de la Tunisie et de la Hongrie, vol.19, pp.105-129, 2004.

R. Nelson, National innovation systems: A comparative analysis, 1993.

R. R. Nelson, The Simple Economics of Basic Scientific Research, Journal of Political Economy, vol.67, pp.297-306, 1959.

R. R. Nelson and N. Rosenberg, National innovation systems, a comparative analysis, Systems of Innovation: Technologies, Institutions and Organizations, pp.3-21, 1993.

R. R. Nelson and S. Winter, An Evolutionary Theory of Economic Change, 1982.

M. W. Nicholson, Intellectual property protection, internalization, and technology transfer, p.48, 2000.

M. Nieto and P. Quevedo, Absorptive capacity, technological opportunity, knowledge spillovers, and innovative effort, vol.25, pp.1141-1157, 2005.

J. Niosi, P. Saviotti, B. Bello, and M. Crow, National system of innovation: in a search for a workable concept, Technology in Society, issue.15, pp.207-227, 1993.

W. D. Nordhaus, An economic theory of technological change, American Economic Review, Papers and Proceedings, vol.59, 1969.

W. D. Nordhaus, The optimum life of a patent: reply, The American Economic Review, vol.62, issue.3, pp.428-431, 1972.

P. Nunnenkamp and J. Spatz, Intellectual property rights and foreign direct investment: A disaggregated analysis, Weltwirtschaftliches Archiv, vol.140, issue.3, pp.393-414, 2004.

T. O'donoghue, S. Scotchmer, and J. F. Thisse, Patent Breadth, Patent Life, and the Pace of Technological Progress, Journal of Economics and Management Strategy, vol.7, issue.1, pp.1-32, 1998.

M. Olson, The Logic of Collective Action, 1965.

V. Oltra, R. Kemp, and F. De-vries, Patents as a measure for ecoinnovation, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00391497

C. Oughton, M. Landabaso, and K. Morgan, The regional innovation paradox: innovation policy and industrial policy, Journal of Technology Transfer, vol.27, pp.97-110, 2002.

J. Owen-smith, M. Riccaboni, F. Pammolli, and W. W. Powe, A comparison of U.S. and European university-industry relations in the life sciences, Management Science, vol.48, p.1, 2002.

J. C. Panzar and R. D. Willig, Economies of scope, American Economic Review, issue.71, pp.268-272, 1981.

W. G. Park and S. Wagh, Index of patent rights, 2000 update, Economic Freedom of the World Annual Report, pp.33-42, 2002.

W. G. Park, Growth and Trade (Frontiers of Economics and Globalization, Intellectual Property, vol.2, pp.289-327, 2009.

P. Patel and K. Pavitt, Patterns of Technological Activity: Their Measurement and Interpretation, pp.14-51, 1995.

P. Patel and K. Pavitt, Technical change and the world economy -Convergence and divergence in technology strategies, pp.147-181, 1995.

J. Pénin, Patents versus ex post rewards: A new look, Research Policy, vol.34, issue.5, pp.641-656, 2005.

A. Perez, Le premier biomédicament 'made in Alsace' », Les Echos, pp.4-2007, 2007.

J. Perrin, Les transferts de technologie », 1983.

A. A. Pharaon and N. Burns, Building a culture of innovation: a case of pharmaceutical industry in Jordan, Journal of Business & Policy Research, vol.5, issue.1, pp.12-27, 2010.

A. Plunket, Firms' inventiveness and localized vertical R&D spillovers, Journal of Innovation Economics, issue.2, pp.147-170, 2009.

M. Polanyi, Review of Economic Studies, issue.11, pp.61-76, 1944.

M. Polanyi, The Tacit Dimension, 1966.

D. Popp, Lessons from patents: using patents to measure technological change in environmental models, Ecological Economics, vol.54, issue.2, pp.209-226, 2005.

J. Porier, Grandes Manoeuvres dans la Pharmacie Américaine, 2009.

M. E. Porter, L'Avantage Concurrentiel des Nations », Dunod, 1993.

M. E. Porter, On Competition, 1998.

J. P. Pradhan, Liberalization, Firm Size and R&D Performance: A Firm Level Study of Indian Pharmaceutical Industry, 2003.

C. Radal and L. Et-alexandre, « Les stratégies de portefeuille de produits des grands laboratoires », MedCost, Economie de la Santé, vol.30, 2000.

R. Rapp and R. Rozek, Benefits and costs of intellectual property protection in developing countries, Journal of World Trade, vol.5, issue.24, pp.75-102, 1990.

J. H. Reichman, Research Handbook on the Protection of Intellectual Property Rights under the WTO Rules, pp.589-622, 2010.

D. Reiffen and M. R. Ward, Generic Drug Industry Dynamics, The Review of Economics and Statistics, vol.87, issue.1, pp.37-49, 2005.

J. F. Reinganum, The Timing of Innovation: Research, Development and Diffusion, Handbook of Industrial Organization, 1989.

J. Reinhard, Accès aux Médicaments et OMC : les Brevets contre la Santé Publique ?, 2001.

B. Rémiche, « Révolution technologique, mondialisation et droit des brevets, Revue Internationale de Droit Economique, vol.XVI, pp.83-124, 2002.

G. B. Richardson, Information and Investment: A Study in the Working of Competitive Economy, 1960.

P. Roffe, C. Spennmann, and J. Von-braun, Intellmectual property right sin free trade agreements: moving beyond TRIPS minimum standards, pp.266-318, 2010.

P. Romer, The Problem of Development: A Conference of the Institute for the Study of Free Enterprise Systems, The Journal of Political Economy, vol.98, issue.5, pp.71-102, 1990.

P. Romer, The origins of endogenous growth, The Journal of Economic Perspectives, vol.8, issue.1, pp.3-22, 1994.

P. M. Romer, Increasing return and long-run growth, The Journal of Political Economy, vol.94, issue.5, pp.1002-1037, 1986.

H. Romijn and M. Albaladejo, Determinants of Innovative Capability in Small Electronics and Software Firms in Southeast England, pp.1053-1067, 2002.

N. Rosenberg, Why Do Firms Do Basic Research (With Their Own Money)?, Research Policy, N°19, pp.165-174, 1990.

R. Rothwell, External networking and innovation in small and medium-sized manufacturing firms in Europe, vol.11, pp.93-112, 1991.

K. Saggi, Trade, foreign direct investment, and international technology transfer: A survey, vol.88, 2000.

P. A. Samuelson, The pure theory of public expenditure, The review of Economics and Statistics, vol.36, pp.387-389, 1954.

P. Saviotti, Systems of Innovation: Technologies, Institutions and Organizations, pp.180-199, 1997.

M. Sawhney and E. Prandelli, Community of creation: Managing distributed innovation in turbulent markets, California Management Review, vol.42, issue.4, pp.24-54, 2000.

A. Saxenian, Regional advantage: Culture and competition in Silicon Valley and Route 128, 1994.

S. Schmidt and J. Et-pierre, Droit de la propriété industrielle, 1996.

P. H. Schneider, International Trade, Economic Growth and Intellectual Property Rights: A Panel Data Study of Developed and Developing Countries, Journal of Development Economics, vol.78, issue.2, pp.529-547, 2005.

J. A. Schumpeter, Théorie de l'Evolution Economique », Dalloz Sirey, 1911.

J. A. Schumpeter and . ;-«-capitalisme, Socialisme et Démocratie », 1942.

S. Scotchmer, Standing on the shoulders of giants: Cumulative research and the patent law, Journal of Economic Perspective, vol.5, p.1, 1991.

S. Scotchmer, Protecting early innovators. Should second-generation products be patentable?, RAND Journal of Economics, vol.27, pp.322-331, 1996.

S. Scotchmer and J. R. Green, Novelty and disclosure in patent law, RAND Journal of Economics, issue.21, pp.131-146, 1990.

R. A. Seaton and M. Cordey-hayes, The development and application of interactive models of industrial technology transfer, pp.45-53, 1993.

D. Shanker, Brazil, Pharmaceutical Industry and WTO, New South Wales, p.87, 2001.

H. Sidgwick, The Principles of Political Economy, 1901.

A. Silva, The importance of Human Resources to the innovative capacity of Portuguese firms, Conferêcia, investigação e intervenção em recursos humanos, 2009.

H. Singh and K. W. Jun, Some new evidence on determinants of foreign direct investment in Developing countries, 1995.

). Singly-(de and F. , L'enquête et ses méthodes : le questionnaire, 127p, Armand Colin, 2008.

A. Smith, An Inquiry into the Nature and Causes of the Wealth of Nations, Modern Library, 1776.

P. J. Smith, Are weak patent rights a barrier to U.S. exports?, Journal of International Economics, vol.48, pp.151-177, 1999.

P. J. Smith, How do foreign patent rights affect U.S. exports, affiliate sales, and licenses?, Journal of International Economics, vol.55, pp.411-439, 2001.

R. M. Solow, A Contribution to the theory of economic growth, Quarterly Journal of Economics, vol.70, issue.1, pp.65-94, 1956.

R. M. Solow, Technical change and the aggregate production function, Review of Economics and Statistics, vol.3, pp.312-320, 1957.

A. M. Spence, The Learning Curve and Competition, Bell Journal of Economics, vol.12, issue.1, pp.49-70, 1981.

E. Stein and C. Daude, Integration and Location of Foreign Investment, OCDE, Global Forum on International Investment, 2001.

S. Stern, M. E. Porter, and J. Furman, The determinants of national innovative capacity, NBER Working Paper, issue.7876, 2000.

G. V. Stevens, Economics and Investment: Explaining Plants and Equipment Spending by U.S. Direct Investors in Argentina, Brazil and Mexico, Journal of International Money and Finance, vol.19, issue.2, pp.153-183, 2000.

J. E. Stiglitz, Information and economic analysis, pp.27-28, 1975.

J. E. Stiglitz, The invisible hand and modern welfare economics, Information Strategy and Public Policy, pp.12-15, 1991.

J. E. Stiglitz, Economic foundations of intellectual property rights, Duke Law Journal, pp.1693-1724, 2008.

M. Storper, The Regional World, 1997.

K. Suzumura, Cooperative and non-cooperative R&D in an oligopoly with spillovers, American Economic Review, vol.82, pp.1307-1320, 1992.

J. Tidd, J. Bessant, and K. Pavitt, Managing Innovation. Integrating Technological, Market and Organizational Change, p.388, 2001.

J. Tidd, J. Bessant, and K. Pavitt, Managing Innovation. Integrating Technological, Market and Organizational Change, p.600, 2005.

J. Tirole, Théorie de l'organisation industrielle, 1993.

J. Tirole and R. Guesnerie, « L'économie de la recherche-développement : introduction à certains travaux théoriques, Revue Economique, vol.36, pp.843-872, 1985.

R. Tommaso, ). Di, E. Lanzoni, and L. Rubini, ONUDI, Organisation des Nations Unies pour le Développement Industriel, 2001.

F. Ülgen, Théories de la firme et stratégies anticoncurrentielles : firme et marché », L'Harmattan, p.332, 2002.

F. Ülgen, « La dynamique de financement de l'innovation », Innovations, Cahiers d'Economie de l'Innovation, pp.45-67, 2007.

D. Uzunidis, « L'Innovation et l'Economie Contemporaine, 2004.

D. Uzunidis, Emergence d'acteurs d'innovation « locaux, 2003.

D. Uzunidis, Développement et Libéralisme. De quoi parle-t-on ? », Lab.RII, Document de Travail, N°105, 2005.

D. Uzunidis, «Innovation et proximité. Entreprises, entrepreneurs et milieux innovateurs», Laboratoire de Recherche sur l'Industrie et l'Innovation (Lab. RII), Cahiers du Lab. RII, Document de Travail no 144, 2007.

D. Uzunidis, « Innovation et proximité. Entreprises, entrepreneurs et milieux innovateurs », La Revue des Sciences de Gestion, pp.13-22, 2010.

N. Vonortas and Y. Kim, Technology licensing, Patents, Innovation and Economic Performance -Proceedings of an OECD Conference, 2004.

M. Weber, Économie et société », traduction du tome 1, 1921.

H. Weeds, Sleeping Patents and Compulsory Licensing: An Options Analysis, p.577, 1999.

N. Weinmann, R&D des compagnies pharmaceutiques : Ruptures et mutations », Mission Prospective pour le compte de la Direction Générale des Entreprises, Observatoire des Stratégies Industrielles, 2008.

B. Wernerfelt, The Resource-Based View of the firm, Strategic Management Journal, vol.5, issue.2, pp.171-180, 1984.

S. G. Winter, V. Weil, and . Snapper, Owning Scientific and Technical Information, Value and Ethical Issues, 1990.

B. D. Wright, The economics of invention incentives: patents, prizes and research contracts, American Economic Review, issue.73, pp.691-707, 1983.

X. Wu, Foreign Direct Investment, Intellectual Property Rights and Wage Inequality in China, China Economic Review, vol.11, pp.361-384, 2000.

S. Maheshwari, Brazilian pharmaceutical industry set for stupendous success, 2010.

, Brazil's Pharmaceutical Industry, Office Suisse d'Expansion Commerciale, 2010.

N. Pharmactua and . Divers, Classement des laboratoires pharmaceutiques dans le monde, 2011.

. Phct, Portail de la Pharmacie Centrale de Tunisie, Chiffres Clefs, 2009.

. Phrma, Pharmaceutical Industry, Profile, 2009.

. Progenericos, O Que São Genéricos ? », Association des Fabricants de Génériques Brésilienne, 2007.

, An executive briefing on pharmaceutical research and development, 2009.

J. Saleh, L'industrie pharmaceutique encourage les jordaniens à se soigner 'local', Rapport Financier Semestriel, 2009.

. Tempus, Academic Ranking of World Universities -ARWU, 2002.

, Accords sur les Droits de la Propriété Intellectuelle qui touchent au Commerce, 1994.

. Décret-loi,