Influence of Age and Sex on Clinical and Therapeutic Features of Laryngopharyngeal Reflux
Jerome Lechien
(1, 2, 3, 4)
,
Thomas Carroll
(5, 6)
,
Francois Bobin
,
Vinciane Muls
(2, 3, 4)
,
Alexandra Rodriguez
(2, 3, 4)
,
Mihaela Horoi
(2, 3, 4)
,
Didier Dequanter
(2, 3, 4)
,
Lise Crevier-Buchman
(7, 8, 9)
,
Stéphane Hans
(8, 9)
,
Sven Saussez
(1, 2, 3, 4)
1
UMons -
Université de Mons
2 CHU - Centre Hospitalier Universitaire Brugmann [Bruxelles]
3 CHU Saint-Pierre
4 ULB - Faculté de Médecine [Bruxelles]
5 HMS - Harvard Medical School [Boston]
6 Brigham and Women's Hospital [Boston]
7 LPP - LPP - Laboratoire de Phonétique et Phonologie - UMR 7018
8 Hôpital Foch [Suresnes]
9 UVSQ Santé - Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil
2 CHU - Centre Hospitalier Universitaire Brugmann [Bruxelles]
3 CHU Saint-Pierre
4 ULB - Faculté de Médecine [Bruxelles]
5 HMS - Harvard Medical School [Boston]
6 Brigham and Women's Hospital [Boston]
7 LPP - LPP - Laboratoire de Phonétique et Phonologie - UMR 7018
8 Hôpital Foch [Suresnes]
9 UVSQ Santé - Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil
Jerome Lechien
- Fonction : Auteur
- PersonId : 799987
- ORCID : 0000-0002-0845-0845
Francois Bobin
- Fonction : Auteur
Lise Crevier-Buchman
- Fonction : Auteur
- PersonId : 175723
- IdHAL : lise-crevier-buchman
- ORCID : 0000-0002-2900-0528
- IdRef : 035788739
Stéphane Hans
- Fonction : Auteur
- PersonId : 759159
- IdRef : 18606439X
Sven Saussez
- Fonction : Auteur
- PersonId : 801623
- ORCID : 0000-0002-3655-1854
Résumé
Objective To explore the influence of age and sex on the clinical presentation and therapeutic response of patients with laryngopharyngeal reflux (LPR). Study Design Prospective study. Setting Prospective multicenter study of 271 patients with a diagnosis of LPR confirmed by impedance-pH monitoring. Methods Patients were prescribed 6 months of diet changes and a combination of pantoprazole and/or alginate depending on the results of their impedance-pH results. The Reflux Symptom Score (RSS) and Reflux Sign Assessment (RSA) were collected at baseline and at 3 and 6 months posttreatment. Data were explored according to sex and age. Results A total of 237 patients completed the evaluations (138 females). On the RSS, patients of the oldest group (>60 years) had lower symptom scores (throat pain, ear pain, odynophagia, chest pain, tongue burning, nausea, halitosis, and indigestion) and lower quality-of-life scores than younger individuals. RSS and RSA outcomes significantly improved from pretreatment to 3 months posttreatment in all groups. Scores on the RSS and RSA continued to improve from 3 to 6 months posttreatment in the elderly group. Females with LPR had a higher score on the RSS at baseline as compared with males. On the RSS, scores significantly improved after 3 months in males and females; however, they continued to improve from 3 to 6 months in the female group. Conclusion Age and sex may influence the clinical presentation and pre- to posttreatment evolution of symptoms and findings. Age and sex differences could be considered in future therapeutic approaches to guide more effective personalized treatment plans for patients with LPR.
Domaines
LinguistiqueFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Influence of Age and Sex on Clinical and Therapeutic Features of Laryngopharyngeal Reflux
|
Résumé |
en
Objective To explore the influence of age and sex on the clinical presentation and therapeutic response of patients with laryngopharyngeal reflux (LPR). Study Design Prospective study. Setting Prospective multicenter study of 271 patients with a diagnosis of LPR confirmed by impedance-pH monitoring. Methods Patients were prescribed 6 months of diet changes and a combination of pantoprazole and/or alginate depending on the results of their impedance-pH results. The Reflux Symptom Score (RSS) and Reflux Sign Assessment (RSA) were collected at baseline and at 3 and 6 months posttreatment. Data were explored according to sex and age. Results A total of 237 patients completed the evaluations (138 females). On the RSS, patients of the oldest group (>60 years) had lower symptom scores (throat pain, ear pain, odynophagia, chest pain, tongue burning, nausea, halitosis, and indigestion) and lower quality-of-life scores than younger individuals. RSS and RSA outcomes significantly improved from pretreatment to 3 months posttreatment in all groups. Scores on the RSS and RSA continued to improve from 3 to 6 months posttreatment in the elderly group. Females with LPR had a higher score on the RSS at baseline as compared with males. On the RSS, scores significantly improved after 3 months in males and females; however, they continued to improve from 3 to 6 months in the female group. Conclusion Age and sex may influence the clinical presentation and pre- to posttreatment evolution of symptoms and findings. Age and sex differences could be considered in future therapeutic approaches to guide more effective personalized treatment plans for patients with LPR.
|
Auteur(s) |
Jerome Lechien
1, 2, 3, 4
, Thomas Carroll
5, 6
, Francois Bobin
, Vinciane Muls
2, 3, 4
, Alexandra Rodriguez
2, 3, 4
, Mihaela Horoi
2, 3, 4
, Didier Dequanter
2, 3, 4
, Lise Crevier-Buchman
7, 8, 9
, Stéphane Hans
8, 9
, Sven Saussez
1, 2, 3, 4
1
UMons -
Université de Mons
( 160918 )
- 20, place du Parc, B7000 Mons
- Belgique
2
CHU -
Centre Hospitalier Universitaire Brugmann [Bruxelles]
( 561087 )
- Place A.Van Gehuchten 4, 1020 Bruxelles
- Belgique
3
CHU Saint-Pierre
( 173628 )
- rue Haute, 322 - 1000 Bruxelles
- Belgique
4
ULB -
Faculté de Médecine [Bruxelles]
( 575848 )
- Campus Erasme - Route de Lennik 808, CP 611, 1070 Bruxelles
- Belgique
5
HMS -
Harvard Medical School [Boston]
( 130467 )
- 25 Shattuck Street Boston, MA 02115
- États-Unis
6
Brigham and Women's Hospital [Boston]
( 300206 )
- 75 Francis St, Boston, MA 02115
- États-Unis
7
LPP -
LPP - Laboratoire de Phonétique et Phonologie - UMR 7018
( 986 )
- Université Sorbonne Nouvelle
Maison de la Recherche
4, rue des Irlandais
75005 PARIS
- France
8
Hôpital Foch [Suresnes]
( 410109 )
- 40 Rue Worth 92150 Suresnes
- France
9
UVSQ Santé -
Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil
( 472222 )
- 2 avenue de la Source de la Bièvre - 78180 Montigny-le-Bretonneux
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2021-06-22
|
Page/Identifiant |
019459982110202
|
Domaine(s) |
|
Mots-clés |
en
Laryngopharyngeal, Reflux, Laryngitis, PH monitoring, Impedance, Reflux episode, Age, Gender, Sex, Treatment
|
DOI | 10.1177/01945998211020284 |
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