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Claude Bernard et ses suiveurs sur la question du curare : enjeux épistémologiques

Abstract : Long lasting polemics about the mechanisms of curare activity took place at the Société de Biologie over thirty years. After a period during which poisoning protocols were developed on various animal species, where Claude Bernard, Vulpian and their colleagues were involved, German electrophysiology combined its results with new histological data about motor end-plates, elaborating a theory in which young physiologists fought against Claude Bernard’s views and finally managed to convince him. According to the new theory proposed by Vulpian, curare blocked transmission between end-plate and muscle. This first draft of the neurotransmission theory helps us to understand the rise of a novel physiology in the context of Claude Bernard’s school with a better integration of disciplines and a more prominent faith in reductionism and materialism.
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Contributor : Jean-Gaël Barbara <>
Submitted on : Wednesday, December 30, 2020 - 10:35:08 AM
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Jean-Gaël Barbara. Claude Bernard et ses suiveurs sur la question du curare : enjeux épistémologiques. Journal de la Société de Biologie, 2009, 203, pp.227 - 234. ⟨10.1051/jbio:2009026⟩. ⟨halshs-03090810⟩



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