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Effet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes

Abstract : This meta-analysis assessed the analgesic effect of a single oral dose of paracetamol versus placebo in adults, in primary care. Parallel randomized studies were searched on MEDLINE, CENTRAL, and EMBASE. We found five studies on sore throat (842 patients) and 12 studies on headache (3433 patients). None related to low back pain. Regardless of the outcome, paracetamol was superior to placebo (Number Need to Treat (NNT)=4-5; Standardized Mean Difference (SMD)=0.51-0.92). Additional clinical trials in other primary care conditions must be conducted.Keywords : analgesic, acetaminophen, placebo, primary health care, meta-analysis.
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Marion Gougain, Moreau Alain, Rémy Boussageon, Gisèle Pickering, François Gueyffier. Effet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes. Thérapie, EDP Sciences, 2017, 72 (5), pp.609 - 613. ⟨10.1016/j.therap.2017.02.004⟩. ⟨halshs-01866986⟩

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