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Reprogramming and Stemness

Abstract : Reprogramming technologies show that cellular identity can be reprogrammed, challenging the classical conception of cell differentiation as an irreversible process. If non-stem cells can be reprogrammed into stem cells, then what is it to be a stem cell, and what kind of property is stemness? This article addresses this question both philosophically and biologically, states the different possibilities, and illustrates their potential consequences for science with the example of anti-cancer therapies.
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Lucie Laplane. Reprogramming and Stemness. Perspectives in Biology and Medicine, Johns Hopkins University Press, 2015, 58 (2), pp.229-246. ⟨10.1353/pbm.2015.0022⟩. ⟨halshs-01279731⟩



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