What history tells us II. The discovery of chaperone function

Michel Morange (1)

1 IHPST - Institut d'Histoire et de Philosophie des Sciences et des Techniques

The conception of chaperone action has evolved since it was initially proposed. This evolution outlines the limits of the notion of function at the macromolecular level. The complex picture of the involvement of chaperones in cell functions can only be understood as the result of the optimisation of organism fitness by natural selection.

Mots clés: Biological Evolution; Heat-Shock Proteins; physiology; History; 20th Century; Molecular Chaperones

Domaines: Histoire, Philosophie et Sociologie des sciences

Michel Morange. What history tells us II. The discovery of chaperone function. Journal of Biosciences, 2005, 30 (4), pp.461-464. ⟨10.1007/BF02703718⟩. ⟨halshs-00791747⟩