Quelle place pour l'épigénétique?

Michel Morange (1)

1 IHPST - Institut d'Histoire et de Philosophie des Sciences et des Techniques

Today, epigenetics is a very fashionable field of research. Modification of DNA by methylation, and of chromatin by histone modification or substitution represents a major fraction of the studies ; but this special issue shows that epigenetic studies are very diverse, and not limited to the study of chromatin. What is common behind these different uses of the word epigenetics ? A brief historical survey shows that epigenetics was invented twice, with different meanings : in the 1940s, by Conrad Waddington, as the study of the relations between the genotype and the phenotype ; in the 1960s, as the global mechanisms of gene regulation involved in differentiation and development ; what is common is that an approach distinct from genetics was in both cases considered as necessary because genetic models were incapable to address these problems. A good way to appreciate the relations between genetics and epigenetics is to realize that the main aim of organisms is to reproduce, and to consider the way organisms perform this task. Genetics is the precise means organisms have invented to reproduce the structure of their macromolecular components ; the genome is also used to control the level and place of this reproduction. All the other means organisms have used to reproduce were more or less the result of tinkering, and constitute the field of epigenetics, with its diversity and richness.

L'étude des modifications épigénétiques de la chromatine constitue aujourd'hui un domaine très actif de recherches. Mais l'intérêt pour l'épigénétique est plus large, ce dont ce cahier thématique s'efforce de rendre compte. Cette diversité ne permet pas une " définition " simple de l'épigénétique. L'étude historique montre comment l'épigénétique est toujours venue combler les insuffisances de la génétique. La distinction entre génétique et épigénétique trouve aussi son sens par rapport à l'objectif de tout être vivant, qui est de se reproduire : à la génétique, la reproduction de la structure primaire des composants macromoléculaires, à l'épigénétique, " le reste ".

Mots clés: épigénétique

Domaines: Histoire, Philosophie et Sociologie des sciences

Michel Morange. Quelle place pour l'épigénétique?. Médecine/Sciences, 2004, 21 (4), pp.367-369. ⟨halshs-00791744⟩