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In vitro modulation of tracheal smooth muscle reactivity by extracts of some Senegalese medicinal plants

Abstract : Scientific validation of pharmacological actions of 7 Senegalese plants used in traditional medicine for the treatment of respiratory illness was carried out. Changes in contractility of isolated rat trachea were assessed in organ chambers. Rings were allowed to equilibrate for 60 min before experiments were carried out, during which time the resting tension was adjusted, as required. Rings were first exposed to methanolic plants extracts (10-2 and 10-1 mg/ml) or solvent. After a 30 min incubation period, they were contracted with acetylcholine in a cumulative manner (10-9 to 10-3M). Extracts from leaves of Guiera senegalensis, Melaleuca leucodendron and Hymenocardia acida elicited a significant dosedependant inhibition of the contractile agonist, suggesting further investigations on its chemical composition, the underlying mechanisms involved and its potential health value. However, in rings preincubated with extracts from Cymbopogon giganteus leaves and Salvadora persica roots, effect of the contractile agonist was not affected. Moreover, a hypereactivity was observed with extracts from Gossypium barbadense leaves and Cassia occidentalis seeds. These results provide evidence that Senegalese herbals may be of interest as valuable source of information for the selection of plants for focussed screening programmes and for therapeutically useful products
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Submitted on : Tuesday, August 30, 2011 - 4:39:51 PM
Last modification on : Monday, January 11, 2021 - 12:16:23 AM


  • HAL Id : halshs-00617873, version 1



Mamadou Sarr, Fatou S. Sarr, Doudou Diop, Modou Oumy Kane, Abdoulaye Ba, et al.. In vitro modulation of tracheal smooth muscle reactivity by extracts of some Senegalese medicinal plants. Journal of medicinal plants research, Academic journals, 2010, 4 (1), pp.013-018. ⟨halshs-00617873⟩



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