DNA-based typing of kell, kidd, MNS, dombrock, colton, and Yt blood groups systems in the French basques. - HAL-SHS - Sciences de l'Homme et de la Société Accéder directement au contenu
Article Dans Une Revue American Journal of Human Biology Année : 2008

DNA-based typing of kell, kidd, MNS, dombrock, colton, and Yt blood groups systems in the French basques.

Résumé

The Basques demonstrate peculiar characteristics regarding blood group systems. Although ABO, Rhesus, and Duffy have been extensively studied in this population, the distribution of other groups remains largely unknown. Therefore, we evaluated the frequency of less-explored- or still noninvestigated blood groups using DNA-based assays and interpreted these data in the view of population genetics. Polymorphisms of KEL (Kell), SLCA14A1 (Kidd), GYPA/GYPB (MNS), ART4 (Dombrock), AQP1 (Colton), and ACHE (Yt) blood group genes were determined from a sample of more than 100 autochthonous French Basques using allele-specific primer PCR (PCR-ASP) methods. Our results were compared with those previously obtained by the use of serology from both Basque and nonBasque European populations. MNS*1 and JK*1 allele frequencies were comparable with those reported from Basque samples. Conversely, the
KEL*1 allele frequency differed significantly. To our knowledge, this is the first time that the other three systems are studied in the Basque population. DO*1 and CO*1 allele frequencies, being respectively 0.35 and 0.96, were significantly inferior to those published from various European populations. There were some discrepancies regarding these six blood
systems when comparing molecular typing with serology. These findings may be explained by differences in either criteria for individual selection or technical assays. Nevertheless, these results constitute additional data to be included in the chapter of Basque biological anthropology

Dates et versions

halshs-00284179 , version 1 (02-06-2008)

Identifiants

Citer

Mhammed Touinssi, Jacques Chiaroni, Anna Degioanni, Thomas Granier, Olivier Dutour, et al.. DNA-based typing of kell, kidd, MNS, dombrock, colton, and Yt blood groups systems in the French basques.. American Journal of Human Biology, 2008, 20, pp.308-311. ⟨10.1002/ajhb.20720⟩. ⟨halshs-00284179⟩

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