Format du dépôt |
Fichier |
Type de dépôt |
Article dans une revue |
Titre |
en
Chromosomal Inversions, Natural Selection and Adaptation in the Malaria Vector Anopheles funestus
|
Résumé |
en
Chromosomal polymorphisms, such as inversions, are presumably involved in the rapid adaptation of populations to local environmental conditions. Reduced recombination between alternative arrangements in heterozygotes may protect sets of locally adapted genes, promoting ecological divergence and potentially leading to reproductive isolation and speciation. Through a comparative analysis of chromosomal inversions and microsatellite marker polymorphisms, we hereby present biological evidence that strengthens this view in the mosquito Anopheles funestus s.s, one of the most important and widespread malaria vectors in Africa. Specimens were collected across a wide range of geographical, ecological, and climatic conditions in Cameroon. We observed a sharp contrast between population structure measured at neutral microsatellite markers and at chromosomal inversions. Microsatellite data detected only a weak signal for population structuring among geographical zones (F-ST < 0.013, P < 0.01). By contrast, strong differentiation among ecological zones was revealed by chromosomal inversions (F-ST > 0.190, P < 0.01). Using standardized estimates of F-ST, we show that inversions behave at odds with neutral expectations strongly suggesting a role of environmental selection in shaping their distribution. We further demonstrate through canonical correspondence analysis that heterogeneity in eco-geographical variables measured at specimen sampling sites explained 89% of chromosomal variance in A. funestus. These results are in agreement with a role of chromosomal inversions in ecotypic adaptation in this species. We argue that this widespread mosquito represents an interesting model system for the study of chromosomal speciation mechanisms and should provide ample opportunity for comparative studies on the evolution of reproductive isolation and speciation in major human malaria vectors.
|
Auteur(s)
|
Diego Ayala
1, 2
, Michael C. Fontaine
3
, Anna Cohuet
1, 4, 2
, Didier Fontenille
1, 2
, Renaud Vitalis
5
, Frédéric Simard
1, 6, 2
1
IRD (Occitanie) -
Institut de Recherche pour le Développement (IRD en Occitanie)
( 1057178 )
- Montpellier
Toulouse
Bordeaux
Sète
Perpignan
- France
2
Caractérisation et contrôle des populations de vecteurs
( 12763 )
- IRD Montpellier - BP 64501 - 34394 Montpellier Cedex 5
- France
-
Institut de Recherche pour le Développement ( 67872 )
3
ESE -
Ecologie Systématique et Evolution
( 135982 )
- bat. 362 91405 ORSAY CEDEX
- France
-
Université Paris-Sud - Paris 11 ( 92966 )
;
-
AgroParisTech ( 148117 )
;
-
Centre National de la Recherche Scientifique UMR8079 ( 441569 )
4
INSSA -
Institut de Recherche en Sciences de la Santé Bobo Dioulasso
( 188289 )
- UNIVERSITE POLYTECHNIQUE
DE BOBO-DIOULASSO
01BP. 1091 Bobo-Dioulasso 01
- Burkina Faso
-
Université Nazi Boni (Bobo-Dioulasso) ( 218084 )
5
UMR CBGP -
Centre de Biologie pour la Gestion des Populations
( 12765 )
- 755 avenue du Campus Agropolis, 34988 Montferrier sur Lez
- France
-
Centre de Coopération Internationale en Recherche Agronomique pour le Développement UMR 55 ( 11574 )
;
-
Institut National de la Recherche Agronomique UMR1062 ( 92114 )
;
-
Centre international d'études supérieures en sciences agronomiques UMR1062 ( 92699 )
;
-
Université de Montpellier UMR1062 ( 410122 )
;
-
Institut de Recherche pour le Développement UMR1062 ( 451860 )
;
-
Institut national d’études supérieures agronomiques de Montpellier ( 474617 )
6
OCEAC -
Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale
( 308414 )
- Yaoundé
- Cameroun
|
Licence |
Paternité
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Volume |
28
|
Numéro |
1
|
Public visé |
Scientifique
|
Date de publication |
2011-01
|
Date de publication électronique |
2010-09-13
|
Page/Identifiant |
745-758
|
URL éditeur |
https://academic.oup.com/mbe/article/28/1/745/986156
|
Version du document |
version éditeur
|
Sous-type de document pour les Articles |
Research article
|
Domaine(s) |
-
Sciences de l'environnement/Environnement et Société
-
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire
-
Sciences de l'Homme et Société/Démographie
-
Sciences de l'Homme et Société/Etudes de l'environnement
-
Sciences du Vivant [q-bio]/Ecologie, Environnement/Santé
-
Sciences du Vivant [q-bio]/Biologie animale
|
Financement |
-
Financial support was provided by the Institut de Recherche pour le Developpement. Fieldwork was supported in part by the National Institutes of Health (R01-AI063508 to Nora J. Besansky). D. A. was supported by a student fellowship grant from Fundacion CAJA MADRID (Madrid, Spain).
|
Mots-clés |
en
Chromosome inversions, Anopheles funestus, Natural selection, Multilocus Genotype Data, Incipient speciation, Differentiation measure, Drosophila-Subobscora, Culicidae group, Time-series
fr
Adaptation locale, malaria, Cameroun, Population génétique-structure, F-Statistics, Gambiae, Afrique
|
DOI |
10.1093/molbev/msq248 |
Base Horizon |
fdi:010080119 |
Pubmed Id |
20837604 |
UT key WOS |
000285418600070 |