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, the OTS had received a total of 50,449 submissions, more than the total number of substances included in the EU REACH program, 2010.
, This means that they could in effect legally be manufactured. However, there was always a significant proportion of new chemicals that made it through the entire NCP PMN process, but that for a variety of reasons were apparently never actually manufactured (i.e., no notice of commencement of manufacture was received by the EPA
, OTS was renamed the Office of Pollution Prevention and Toxics (OPPT) in around 1992. The major reorganization of that office in 1997 resulted in the morphing of HERD into what became the Risk Assessment Division (RAD)
, Source: interview with the authors
, Source: interview with the authors
, its usefulness in QSAR modelling can mainly be credited to the strategic approach taken in the development of the database. The express purpose of the fathead minnow database was to build relevant and reliable QSAR models based on data that covered a wide range of structure space and thereby a wide range of possible modes of toxicity. All toxicity tests were conducted in the same laboratory following standard test methods. Both the dilution water and fish used were from a single source. Chemicals used were of the highest purity, with all treatment concentrations measured under stringent data quality objectives. By controlling for these factors, variability in the test results was minimized and thereby increased confidence that variation in toxicity was related to variation in chemical structure and associated toxicological properties, p.19, 2015.
, Thirty-one (31) of them cite their "Source" as being developed by EEB scientists (Vincent Nabholz and/or Richard Clements, etc.), and four of them list their, There is a list of the 49 SARs in the OTS QSAR Manual (EPA, 1988: ix)
, Source: interview with the authors
, There was a decrease of almost 40% in NCP funding and a decrease of about 33% in NCP staffing between 1990 and 1995, even though the number of PMNs received seemed to trend upward
, When one launches the ECOSAR program on a computer, a special warning appears in a window saying "it is a screening-level tool