Disconnecting force from money: effects of basal ganglia damage on incentive motivation.

Liane Schmidt; Baudouin Forgeot d'Arc; Gilles Lafargue; Damien Galanaud; Virginie Czernecki; David Grabli; Michael W. Schüpbach; Andreas Hartmann; Richard Lévy; Bruno Dubois; Mathias Pessiglione

HAL: hal-00333398, version 1

PubMed: 18344560

DOI: 10.1093/brain/awn045

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Disconnecting force from money: effects of basal ganglia damage on incentive motivation.
Schmidt L., d'Arc B. F., Lafargue G., Galanaud D., Czernecki V., Grabli D., Schüpbach M. W., Hartmann A., Lévy R., Dubois B. et al
Brain 131, Pt 5 (2008) 1303-10 - http://hal.archives-ouvertes.fr/hal-00333398

Publication type:

Article in peer-reviewed journal

Subject:

Life Sciences/Neurons and Cognition

Title:

Disconnecting force from money: effects of basal ganglia damage on incentive motivation.

Author(s):

Liane Schmidt, Baudouin Forgeot d'Arc, Gilles Lafargue ¹, Damien Galanaud ^2, 3, Virginie Czernecki, David Grabli, Michael W. Schüpbach ⁴, Andreas Hartmann ^5, 6, 7, Richard Lévy ^8, 9, 10, Bruno Dubois ^11, 12, 13, Mathias Pessiglione

Laboratory:

1:	Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP)

	http://LNFP.dr18.cnrs.fr

	CNRS : UMR8160 – Université Lille II - Droit et santé

	Service EFV Hôpital Roger Salengro CHRU Lille 59037 Lille Cedex

	France

2:	Centre de résonance magnétique biologique et médicale (CRMBM)

	CNRS : UMR6612 – Université de la Méditerranée - Aix-Marseille II

	27 Bvd Jean Moulin 13385 MARSEILLE CEDEX 05

	France

3:	Service de neuro-radiologie

	Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Pitié-Salpêtrière – Université Pierre et Marie Curie [UPMC] - Paris VI

	47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13

	France

4:	Neurologie et thérapeutique expérimentale

	http://www.u289.ifrns.chups.jussieu.fr/

	INSERM : U679 – IFR70 – Université Pierre et Marie Curie [UPMC] - Paris VI

	GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13

	France

5:	CRPCC - Laboratoire de Psychologie Sociale. UHB (LAUREPS)

	MEN : EA1285 – Université de Rennes II - Haute Bretagne

	UFR Sciences Humaines. Place du Recteur Henri Le Moal. 35043 RENNES CEDEX

	France

6:	Institut de Mathématiques de Bordeaux (IMB)

	http://www.math.u-bordeaux.fr/IMB/

	CNRS : UMR5251 – Université Sciences et Technologies - Bordeaux I – Université Victor Segalen - Bordeaux II

	351 cours de la Libération 33405 TALENCE CEDEX

	France

7:	Laboratoire de Physique Statistique de l'ENS (LPS)

	http://www.lps.ens.fr/

	CNRS : UMR8550 – Université Pierre et Marie Curie [UPMC] - Paris VI – Université Paris VII - Paris Diderot – Ecole normale supérieure de Paris - ENS Paris

	France

8:	Département de Mécanique des fluides et énergétique (ONERA - MFE)

	http://www.onera.fr/onera/mfe/

	ONERA

	29, avenue de la Division Leclerc BP 72 F-92322 Châtillon cedex

	France

9:	Bureau d'économie théorique et appliquée (BETA)

	http://cournot.u-strasbg.fr/users/beta/beta.html

	CNRS : UMR7522 – Université Louis Pasteur - Strasbourg I

	P E G E 61 avenue de la Forêt Noire 67085 STRASBOURG CEDEX

	France

10:	Neuro-anatomie fonctionnelle du comportement et de ses troubles

	INSERM : U610 – IFR70 – Université Pierre et Marie Curie [UPMC] - Paris VI

	GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 Paris Cedex 13

	France

11:	Centre du Langage et de Neuropsychologie

	Assistance publique - Hôpitaux de Paris (AP-HP)

	47 Bd de l'Hôpital 75651 Paris Cedex 13

	France

12:	Département de Neurologie

	Hôpital de la Salpétrière – Assistance publique - Hôpitaux de Paris (AP-HP) – IFR70

	47 Bd de l'Hôpital 75651 Paris Cedex 13

	France

13:	Institut d'Electronique du Solide et des Systèmes (InESS)

	http://www-iness.c-strasbourg.fr/

	CNRS : UMR7163 – Université Louis Pasteur - Strasbourg I

	23, rue du Loess - BP 20 CR 67037 STRASBOURG Cedex 2

	France

Abstract:

Bilateral basal ganglia lesions have been reported to induce a particular form of apathy, termed auto-activation deficit (AAD), principally defined as a loss of self-driven behaviour that is reversible with external stimulation. We hypothesized that AAD reflects a dysfunction of incentive motivation, a process that translates an expected reward (or goal) into behavioural activation. To investigate this hypothesis, we designed a behavioural paradigm contrasting an instructed (externally driven) task, in which subjects have to produce different levels of force by squeezing a hand grip, to an incentive (self-driven) task, in which subjects can win, depending on their hand grip force, different amounts of money. Skin conductance was simultaneously measured to index affective evaluation of monetary incentives. Thirteen AAD patients with bilateral striato-pallidal lesions were compared to thirteen unmedicated patients with Parkinson's; disease (PD), which is characterized by striatal dopamine depletion and regularly associated with apathy. AAD patients did not differ from PD patients in terms of grip force response to external instructions or skin conductance response to monetary incentives. However, unlike PD patients, they failed to distinguish between monetary incentives in their grip force. We conclude that bilateral striato-pallidal damage specifically disconnects motor output from affective evaluation of potential rewards.

Fulltext language:

English

Journal:

Brain (Brain)
Publisher	Oxford University Press (OUP): Policy B
ISSN	0006-8950 (eISSN : 1460-2156)

Audience:

international

Publication date:

2008-05

Submission date:

2008-03-15

Volume:

131

Issue:

Pt 5

Page, identifiant, ...:

1303-10

MeSH Classification:

Adult – Aged – 80 and over – Basal Ganglia – Basal Ganglia Diseases – Brain Mapping – Female – Galvanic Skin Response – Hand Strength – Humans – Magnetic Resonance Imaging – Male – Middle Aged – Motivation – Parkinson Disease – Psychomotor Disorders – Psychomotor Performance – Reward – Severity of Illness Index


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http://hal.archives-ouvertes.fr/hal-00333398
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From: Anny Wartel <>
Submitted on: Thursday, 23 October 2008 10:48:57
Updated on: Thursday, 23 October 2008 10:48:57