 |
|
 |
|
|
|
| HAL : hal-00333398, version 1 |
| PubMed : 18344560 |
| DOI : 10.1093/brain/awn045 |
| Fiche détaillée |  Récupérer au format |
|
|
| Brain 131, Pt 5 (2008) 1303-10 |
|
|
|
|
| Disconnecting force from money: effects of basal ganglia damage on incentive motivation. |
|
|
| Liane SchmidtBaudouin Forgeot d'Arc |
|
|
| (05/2008) |
|
|
|
| Bilateral basal ganglia lesions have been reported to induce a particular form of apathy, termed auto-activation deficit (AAD), principally defined as a loss of self-driven behaviour that is reversible with external stimulation. We hypothesized that AAD reflects a dysfunction of incentive motivation, a process that translates an expected reward (or goal) into behavioural activation. To investigate this hypothesis, we designed a behavioural paradigm contrasting an instructed (externally driven) task, in which subjects have to produce different levels of force by squeezing a hand grip, to an incentive (self-driven) task, in which subjects can win, depending on their hand grip force, different amounts of money. Skin conductance was simultaneously measured to index affective evaluation of monetary incentives. Thirteen AAD patients with bilateral striato-pallidal lesions were compared to thirteen unmedicated patients with Parkinson's; disease (PD), which is characterized by striatal dopamine depletion and regularly associated with apathy. AAD patients did not differ from PD patients in terms of grip force response to external instructions or skin conductance response to monetary incentives. However, unlike PD patients, they failed to distinguish between monetary incentives in their grip force. We conclude that bilateral striato-pallidal damage specifically disconnects motor output from affective evaluation of potential rewards. |
|
|
|
|
|
|
|
|
|
|
|
| 1 : | Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP) |
|
|
|
CNRS : UMR8160 – Université Lille II - Droit et santé |
|
|
| 2 : | Centre de résonance magnétique biologique et médicale (CRMBM) |
|
|
|
CNRS : UMR6612 – Université de la Méditerranée - Aix-Marseille II |
|
|
| 3 : | Service de neuro-radiologie |
|
|
|
Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Pitié-Salpêtrière – Université Pierre et Marie Curie [UPMC] - Paris VI |
|
|
| 4 : | Neurologie et thérapeutique expérimentale |
|
|
|
INSERM : U679 – IFR70 – Université Pierre et Marie Curie [UPMC] - Paris VI |
|
|
| 5 : | CRPCC - Laboratoire de Psychologie Sociale. UHB (LAUREPS) |
|
|
|
MEN : EA1285 – Université de Rennes II - Haute Bretagne |
|
|
| 6 : | Institut de Mathématiques de Bordeaux (IMB) |
|
|
|
CNRS : UMR5251 – Université Sciences et Technologies - Bordeaux I – Université Victor Segalen - Bordeaux II |
|
|
| 7 : | Laboratoire de Physique Statistique de l'ENS (LPS) |
|
|
|
CNRS : UMR8550 – Université Pierre et Marie Curie [UPMC] - Paris VI – Université Paris VII - Paris Diderot – Ecole normale supérieure de Paris - ENS Paris |
|
|
| 8 : | Département de Mécanique des fluides et énergétique (ONERA - MFE) |
|
|
|
ONERA |
|
|
| 9 : | Bureau d'économie théorique et appliquée (BETA) |
|
|
|
CNRS : UMR7522 – Université Louis Pasteur - Strasbourg I |
|
|
| 10 : | Neuro-anatomie fonctionnelle du comportement et de ses troubles |
|
|
|
INSERM : U610 – IFR70 – Université Pierre et Marie Curie [UPMC] - Paris VI |
|
|
| 11 : | Centre du Langage et de Neuropsychologie |
|
|
|
Assistance publique - Hôpitaux de Paris (AP-HP) |
|
|
| 12 : | Département de Neurologie |
|
|
|
Hôpital de la Salpétrière – Assistance publique - Hôpitaux de Paris (AP-HP) – IFR70 |
|
|
| 13 : | Institut d'Electronique du Solide et des Systèmes (InESS) |
|
|
|
CNRS : UMR7163 – Université Louis Pasteur - Strasbourg I |
|
|
|
|
|
|
|
|
|
| Domaine | : | Sciences du Vivant/Neurosciences |
| hal-00333398, version 1 | |
| http://hal.archives-ouvertes.fr/hal-00333398 | |
| oai:hal.archives-ouvertes.fr:hal-00333398 | |
| Contributeur : Anny Wartel | |
| Soumis le : Jeudi 23 Octobre 2008, 10:48:57 | |
| Dernière modification le : Jeudi 23 Octobre 2008, 10:48:57 | |
